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Comparative Study
. 1986 Jun;22(2):95-8.
doi: 10.1016/0165-4608(86)90168-8.

High resolution chromosome analysis of constitutional and acquired t(15;17) maps c-erbA to subband 17q11.2

F Mitelman, G Manolov, Y Manolova, R Billström, S Heim, U Kristoffersson, N Mandahl, M T Ferro, C San Roman
Comparative Study

High resolution chromosome analysis of constitutional and acquired t(15;17) maps c-erbA to subband 17q11.2

F Mitelman et al. Cancer Genet Cytogenet. 1986 Jun.

Abstract

High resolution chromosome analysis was performed on bone marrow cells from four patients with acute promyelocytic leukemia and t(15;17), and in lymphocytes from two unrelated, phenotypically normal persons with an apparently identical constitutional translocation. Scrutiny of prophase-prometaphase chromosomes localized the breakpoints in all six cases to subbands 15q22.3 and 17q11.2. Molecular genetic studies have localized the oncogene c-erbA to chromosome #17 between the breakpoints of the constitutional and the acquired anomaly. The present results, therefore, map c-erbA to subband 17q11.2.

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