Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2021 Sep 18:2021:5553356.
doi: 10.1155/2021/5553356. eCollection 2021.

Bacterial Profile, Antimicrobial Susceptibility Pattern, and Associated Factors of Community- and Hospital-Acquired Urinary Tract Infection at Dessie Referral Hospital, Dessie, Northeast Ethiopia

Berhanu Adugna  1 , Bekele Sharew  2 , Mohabaw Jemal  3
Affiliations

Bacterial Profile, Antimicrobial Susceptibility Pattern, and Associated Factors of Community- and Hospital-Acquired Urinary Tract Infection at Dessie Referral Hospital, Dessie, Northeast Ethiopia

Berhanu Adugna et al. Int J Microbiol. .

Abstract

Background: Bacterial urinary tract infection is among the most common community and hospital-acquired infections. Therefore, to know the status of the community and hospital-acquired urinary tract infection, antimicrobial susceptibility patterns, and associated factors among urinary tract infection profiles are essential to physicians and health workers to implement appropriate intervention.

Methods: An institution-based cross-sectional study was conducted among 422 urinary tract infection suspected patients. All isolates were identified by standard microbiological techniques, and their antibiotic susceptibility was done by the Kirby-Bauer disc diffusion method. Data were entered using EpiData version 3.1 and analyzed by SPSS software version 20. P value < 0.05 at 95% CI was considered statistically significant.

Result: Of 422 urine samples processed, 100 (23.7%) yielded bacterial isolates. About 50(30.7%) and 50(19.3%) were bacterial isolates from the community and hospitalized patients, respectively. E. coli 44/103(42.7%) predominated across the two groups, followed by S. aureus 25/103(24.3%), CONs, 14/103(13.5%), Klebsiella spp. 7/103(6.78), Proteus spp. 3/103(2.91), and Enterococcus spp. 3/103 (2.91%). Pseudomonas spp. 3/103 (2.91), Citrobacter spp. 2/103(1.94%), and Acinetobacter spp. 1/103(0.999), which were isolated from only the hospitalized patients. Meropenem susceptibly was 100% in both study groups and Ampicillin resistance was documented as 83.3% to 100% and 76.9% to 100% in hospitalized and community-acquired samples, respectively.

Conclusion: This study found a high prevalence of bacterial urinary tract infection in the study area and a high rate of bacterial resistance was observed to most antimicrobial drugs tested. Meropenem and nitrofurantoin were the most active drugs for urinary tract infections. Therefore, expanding routine bacterial culture and identification with antimicrobial susceptibility testing and strengthening regular surveillance systems are essential for appropriate patient care.

PubMed Disclaimer

Conflict of interest statement

The authors declare that they have no conflicts of interest.

Figures

Figure 1
Figure 1
Bacterial growth results in the culture media from a total urine sample processed at Dessie Referral Hospital, Dessie.
Figure 2
Figure 2
Distribution of isolates varies in the duration of catheterization at Dessie Referral Hospital.
See this image and copyright information in PMC

Similar articles

See all similar articles

Cited by

See all "Cited by" articles

References

    1. Chaturvedi A., Garg R., Singh V. A. Comparative evaluation of different culture media for the isolation and identification of common urinary pathogens. International Journal of Research in Medical Sciences. 2017;5(8):3676–3679. doi: 10.18203/2320-6012.ijrms20173584. - DOI
    1. Otajevwo F. D. Urinary tract infection among symptomatic outpatients visiting a tertiary hospital based in midwestern Nigeria. Global Journal of Health Science. 2013;5(2):187–99. doi: 10.5539/gjhs.v5n2p187. - DOI - PMC - PubMed
    1. Nicolle L. E. Urinary tract infection. Nephrology Secrets. 2012;18:340–345. doi: 10.1016/b978-1-4160-3362-2.00056-7. - DOI
    1. Arjunan M., Al-Salamah A. A., Amuthan M. Prevalence and antibiotics susceptibility of uropathogens in patients from a rural environment, Tamilnadu. American Journal of Infectious Diseases. 2010;6(2):29–33. doi: 10.3844/ajidsp.2010.29.33. - DOI
    1. Pai V., Nair B. Etiology and sensitivity of uropathogens in outpatients and inpatients with urinary tract infection: implications on empiric therapy. Annals of Tropical Medicine and Public Health. 2012;5(3):p. 181. doi: 10.4103/1755-6783.98610. - DOI

LinkOut - more resources