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. 2021 Jul 26;29(3):370-376.
doi: 10.5606/tgkdc.dergisi.2021.20143. eCollection 2021 Jul.

Positron emission tomography/computed tomography findings of lung invasive adenocarcinoma subgroups and comparison of their short-term survivals

Bahar Ağaoğlu Şanlı  1 , Fatma İlknur Ulugün  1 , Volkan Karaçam  1 , Duygu Gürel  2 , Recep Bekiş  3 , Aydın Şanlı  1 , Nezih Özdemir  1
Affiliations

Positron emission tomography/computed tomography findings of lung invasive adenocarcinoma subgroups and comparison of their short-term survivals

Bahar Ağaoğlu Şanlı et al. Turk Gogus Kalp Damar Cerrahisi Derg. .

Abstract

Background: The aim of this study was to compare the maximum standardized uptake values on positron emission tomography/ computed tomography and survival of lung invasive adenocarcinoma subgroups.

Methods: Between January 2010 and January 2016, a total of 152 patients (112 males, 40 females; mean age: 64.2±8.6 years; range, 41 to 88 years) who underwent lung resection for an invasive adenocarcinoma were retrospectively analyzed. The patients were divided into subgroups as follows: acinar, lepidic, micropapillary, papillary, and solid. The maximum standardized uptake values in the imaging study and their relationship with survival were examined.

Results: There were 84 acinar (55%), 31 solid (20%), 23 lepidic (15%), nine papillary (5%), and five micropapillary (3%) cases. The positron emission tomography/computed tomography enhancement showed a statistically significant difference among the subgroups (p=0.004). The solid subgroup was the most involved (9.76), followed by micropapillary (8.98), acinar (8.06), papillary (5.82), and lepidic (4.23) subgroups, respectively. According to Tumor, Node, Metastasis staging, Stage I was present in 48.68% (n=74) of the cases, Stage II in 25.0% (n=38), Stage III in 25.0% (n=38), and Stage IV in 1.31% (n=2). The one-year, three-year, and five-year survival rates were significantly different among the disease stages (p=0.01). The longest survival duration was in the lepidic subgroup, although it did not reach statistical significance among the subgroups (p=0.587).

Conclusion: The evaluation of invasive adenocarcinomas based on maximum standardized uptake values provides valuable information and may guide neoadjuvant and adjuvant therapies in the future.

Keywords: Classification; computed tomography; lung adenocarcinoma; positron emission tomography; survival.

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Conflict of interest statement

Conflict of Interest: The authors declared no conflicts of interest with respect to the authorship and/or publication of this article.

Figures

Figure 1
Figure 1. 1-year, 3-year and 5-year survival rates of the patients in each stage.
Figure 2
Figure 2. Mean survival durations of subgroups (months).
Figure 3
Figure 3. 1-year, 3-year and 5-year survival rates of the subgroups.
See this image and copyright information in PMC

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