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Review
. 2021 Nov;13(21):1885-1906.
doi: 10.4155/fmc-2021-0096. Epub 2021 Sep 30.

The role of microRNA-21 in the onset and progression of cancer

Ashutosh Singh  1 , Ashutosh Kumar Singh  1 , Rajanish Giri  1 , Dhruv Kumar  2 , Rohit Sharma  3 , Martin Valis  4 , Kamil Kuca  5 , Neha Garg  6
Affiliations
Review

The role of microRNA-21 in the onset and progression of cancer

Ashutosh Singh et al. Future Med Chem. 2021 Nov.

Abstract

MicroRNAs (miRNAs), a class of small noncoding RNA, posttranscriptionally regulate the expression of genes. Aberrant expression of miRNA is reported in various types of cancer. Since the first report of oncomiR-21 involvement in the glioma, its upregulation was reported in multiple cancers and was allied with high oncogenic property. In addition to the downregulation of tumor suppressor genes, the miR-21 is also associated with cancer resistance to various chemotherapy. The recent research is appraising miR-21 as a promising cancer target and biomarker for early cancer detection. In this review, we briefly explain the biogenesis and regulation of miR-21 in cancer cells. Additionally, the review features the assorted genes/pathways regulated by the miR-21 in various cancer and cancer stem cells.

Keywords: apoptosis; cancer; cancer stem cells; carcinogenesis; metastasis; miR-21; miRNA.

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