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. 2021;31(5):67-78.
doi: 10.1615/CritRevEukaryotGeneExpr.2021039540.

Behind the Scene: Surprises and Snags of Pseudogenes

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Behind the Scene: Surprises and Snags of Pseudogenes

Hafiz Ishfaq Ahmad et al. Crit Rev Eukaryot Gene Expr. 2021.

Abstract

The junk DNA "pseudogenes," known as genomic fossils, are characterized by their ubiquitousness and abundance within the genomic structure. These genomics sets are recognized by the potential activity of meta-regulating the parent genes; these are transcribed into interfering RNA, consequently acting on miRNA concentration, thereby shedding light on the crosstalk of the pseudogenes' miRNA, siRNA, lncRNA/tumor therapy co-relationship. Moreover, an upcoming visualization regarding pseudogenes is under investigation, which describes the potentiality of pseudogenes as a fundamental component of cancerous evolutionary processing tools. Accordingly, here is a systematic review covering pseudobirth, pseudosignatures, and functional properties of pseudogenes, concluding that these pseudogenes are hypothetically predictive tumor therapies.

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