A treasure trove of molecular scissors

Affiliations

Comment

François Rousset et al. Science. 2021 Oct.

. 2021 Oct;374(6563):37-38.

doi: 10.1126/science.abm2239. Epub 2021 Sep 30.

¹ Department of Molecular Genetics, Weizmann Institute of Science, Rehovot, Israel.

Abstract

Ancestral RNA-guided nucleases greatly expand the toolbox for gene editing.

The widespread IS200/IS605 transposon family encodes diverse programmable RNA-guided endonucleases.
Altae-Tran H, Kannan S, Demircioglu FE, Oshiro R, Nety SP, McKay LJ, Dlakić M, Inskeep WP, Makarova KS, Macrae RK, Koonin EV, Zhang F. Altae-Tran H, et al. Science. 2021 Oct;374(6563):57-65. doi: 10.1126/science.abj6856. Epub 2021 Sep 9. Science. 2021. PMID: 34591643 Free PMC article.