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. 2021 Sep 30;10(39):e0070921.
doi: 10.1128/MRA.00709-21. Epub 2021 Sep 30.

Complete Genome Sequences of Enterovirus D68 Clade A and D Strains in the Philippines

Michiko Okamoto  1 , Masahiro Sakamoto  1 , Clyde Dapat  1 , Mayuko Saito  1 , Mariko Saito-Obata  1 , Raita Tamaki  1 , Socorro P Lupisan  2 , Beatriz P Quiambao  2 , Hitoshi Oshitani  1
Affiliations

Complete Genome Sequences of Enterovirus D68 Clade A and D Strains in the Philippines

Michiko Okamoto et al. Microbiol Resour Announc. .

Abstract

Complete genome sequences were determined for 4 clade A and 12 clade D enterovirus D68 strains detected in nasopharyngeal swabs from children with acute respiratory illness in the Philippines. These sequence data will be useful for future epidemiological monitoring, including watching for viral evolution.

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Figures

FIG 1
FIG 1
Amino acid substitution of the structural protein of EV-D68. The P1 region sequences (except VP4) of the EV-D68 strains of clades A and D analyzed in this study were aligned, and the numbering was based on strain Fermon (GenBank accession number AY426531.1). Representative strains of clades A and D are shown in open black boxes. The positions where sequences had amino acid residues identical to TTa-11-Ph224 (clade A) are indicated by dots. Solid blue and magenta indicate nonsynonymous substitutions in clade D in a community in Biliran Island after 2016. The open blue boxes represent the BC, DE, and GH loop regions. The asterisk indicates the protease cleavage site for VP3/VP1.
See this image and copyright information in PMC

References

    1. Holm-Hansen CC, Midgley SE, Fischer TK. 2016. Global emergence of enterovirus D68: a systematic review. Lancet Infect Dis 16:e64–e75. doi:10.1016/S1473-3099(15)00543-5. - DOI - PubMed
    1. Imamura T, Oshitani H. 2015. Global reemergence of enterovirus D68 as an important pathogen for acute respiratory infections. Rev Med Virol 25:102–114. doi:10.1002/rmv.1820. - DOI - PMC - PubMed
    1. Du J, Zheng B, Zheng W, Li P, Kang J, Hou J, Markham R, Zhao K, Yu X-F. 2015. Analysis of enterovirus 68 strains from the 2014 North American outbreak reveals a new clade, indicating viral evolution. PLoS One 10:e0144208. doi:10.1371/journal.pone.0144208. - DOI - PMC - PubMed
    1. Gong Y-N, Yang S-L, Shih S-R, Huang Y-C, Chang P-Y, Huang C-G, Kao K-C, Hu H-C, Liu Y-C, Tsao K-C. 2016. Molecular evolution and the global reemergence of enterovirus D68 by genome-wide analysis. Medicine (Baltimore) 95:e4416. doi:10.1097/MD.0000000000004416. - DOI - PMC - PubMed
    1. Yip CCY, Lo JYC, Sridhar S, Lung DC, Luk S, Chan K-H, Chan JFW, Cheng VCC, Woo PCY, Yuen K-Y, Lau SKP. 2017. First report of a fatal case associated with EV-D68 infection in Hong Kong and emergence of an interclade recombinant in China revealed by genome analysis. Int J Mol Sci 18:1065. doi:10.3390/ijms18051065. - DOI - PMC - PubMed

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