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. 1986 Jun;83(12):4566-7.
doi: 10.1073/pnas.83.12.4566.

Presence and formation of codeine and morphine in the rat

J Donnerer, K Oka, A Brossi, K C Rice, S Spector

Presence and formation of codeine and morphine in the rat

J Donnerer et al. Proc Natl Acad Sci U S A. 1986 Jun.

Abstract

Endogenous codeine and morphine were identified in rat brain by immunological determination following HPLC. To demonstrate occurrence of a biosynthetic pathway to morphine in mammals similar to that used by the poppy plant, (+)-salutaridine, (-)-thebaine, and (-)-codeine were administered to rats intravenously. These compounds, which are intermediates in the synthesis of morphine in Papaver somniferum, caused a marked increase in the codeine and morphine levels in rat tissues. This provides evidence for a biosynthetic pathway to morphine in mammalians.

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References

    1. J Pharmacol Exp Ther. 1971 Aug;178(2):253-8 - PubMed
    1. J Pharmacol Exp Ther. 1975 Nov;195(2):303-10 - PubMed
    1. Proc Natl Acad Sci U S A. 1976 Jun;73(6):2132-6 - PubMed
    1. Br J Pharmacol. 1977 Dec;61(4):639-47 - PubMed
    1. J Chem Soc. 1965 May;33:3323-32 - PubMed

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