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. 1986 Jun;83(12):4568-71.
doi: 10.1073/pnas.83.12.4568.

Modulation of granule cell migration by a glia-derived protein

J Lindner, J Guenther, H Nick, G Zinser, H Antonicek, M Schachner, D Monard

Modulation of granule cell migration by a glia-derived protein

J Lindner et al. Proc Natl Acad Sci U S A. 1986 Jun.

Abstract

Cultured explants from early postnatal mouse cerebellum were used to examine the influence of a 43-kDa glia-derived neurite-promoting factor (GdNPF) on the migration of [3H]thymidine-labeled granule cell neurons. GdNPF, which is a potent serine protease inhibitor, significantly reduced the extent of granule cell migration in a dose-dependent manner. This effect could be neutralized by addition of thrombin, which binds GdNPF. Other protease inhibitors such as aprotinin, hirudin, soybean trypsin inhibitor, leupeptin, 6-aminocaproic acid, and D-Phe-Pro-ArgCH2Cl do not show this inhibitory effect. These results demonstrate that a glia-derived protein can regulate the migration of postmitotic neurons, an important cellular event in the development of the nervous system.

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