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Editorial
. 2021 Oct 5;78(14):1404-1406.
doi: 10.1016/j.jacc.2021.08.007.

Initial Triple Pharmacotherapy in Pulmonary Arterial Hypertension: Is More Necessarily Better?

Jane A Leopold  1
Affiliations
Editorial

Initial Triple Pharmacotherapy in Pulmonary Arterial Hypertension: Is More Necessarily Better?

Jane A Leopold. J Am Coll Cardiol. .
No abstract available

Keywords: combination therapy; pulmonary arterial hypertension; right ventricle; triple therapy.

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Conflict of interest statement

Funding Support and Author Disclosures Dr Leopold is supported by National Institutes of Health grant U01 125215 and American Heart Association grant 19AIML34980000; has received research funding (to her institution) from Astellas; is a consultant for Abbott Vascular and United Therapeutics; and is a site principal investigator for a study sponsored by Aria CV.

Comment on

References

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    1. Galie N, Barbera JA, Frost AE et al. Initial Use of Ambrisentan plus Tadalafil in Pulmonary Arterial Hypertension. N Engl J Med 2015;373:834–44. - PubMed
    1. Sitbon O, Channick R, Chin KM et al. Selexipag for the Treatment of Pulmonary Arterial Hypertension. N Engl J Med 2015;373:2522–33. - PubMed
    1. Chin KM, Sitbon O, Doelberg M et al. TRITON: Initial triple oral versus double oral combination therapy in newly diagnosed pulmonary arterial hypertension. J Am Coll Card 2021.
    1. Amsallem M, Sweatt AJ, Aymami MC et al. Right Heart End-Systolic Remodeling Index Strongly Predicts Outcomes in Pulmonary Arterial Hypertension: Comparison With Validated Models. Circ Cardiovasc Imaging 2017;10. - PMC - PubMed

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