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Editorial
. 2021 Oct 5;78(14):1450-1452.
doi: 10.1016/j.jacc.2021.08.006.

The Enigma of PCSK9 Regulation: Leveraging Therapeutics Towards Mechanistic Understanding

Sascha N Goonewardena  1 , Robert S Rosenson  2
Affiliations
Free article
Editorial

The Enigma of PCSK9 Regulation: Leveraging Therapeutics Towards Mechanistic Understanding

Sascha N Goonewardena et al. J Am Coll Cardiol. .
Free article
No abstract available

Keywords: LDL cholesterol; LDL receptor; PCSK9; cholesterol homeostasis; monoclonal antibodies; turnover studies.

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Conflict of interest statement

Funding Support and Author Disclosures Dr Rosenson has received research funding to his institution from Amgen, National Institutes of Health, Novartis, and Regeneron; has received consulting fees from Amgen, Amyrt, C5, CVS Caremark, Regeneron, and 89Bio; has received nonpromotional speaker fees from Amgen, Kowa, and Regeneron; has received royalties from Wolters Kluwer (UpToDate); and has stock holdings in MediMergent. Dr Goonewardena has reported that he has no relationships relevant to the contents of this paper to disclose.

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