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Comment
. 2021 Nov;27(11):1019-1021.
doi: 10.1016/j.molmed.2021.09.002. Epub 2021 Sep 28.

Special delivery! CAR-T cells transport RN7SL1 to the tumor microenvironment

W Sam Nutt  1 , Shivani Srivastava  2
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Special delivery! CAR-T cells transport RN7SL1 to the tumor microenvironment

W Sam Nutt et al. Trends Mol Med. 2021 Nov.

Abstract

In a recent Cell publication, Johnson et al. demonstrate that engineering chimeric antigen receptor (CAR)-T cells to produce RN7SL1, a novel RNA adjuvant that activates the viral sensors RIG-I and MDA5, improves intrinsic CAR-T cell function, activates tumor-infiltrating myeloid cells, and enhances endogenous tumor-specific T cell responses, resulting in improved tumor control despite CAR antigen loss in multiple mouse models.

Keywords: CAR-T cells; extracellular vesicles; pattern recognition receptors.

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