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Case Reports
. 2022 Jul 1;68(7):e124-e127.
doi: 10.1097/MAT.0000000000001594. Epub 2022 Sep 28.

Polyuria due to Pressure Natriuresis in Venoarterial Extracorporeal Membrane Oxygenation

Raphael J Rosen  1 , Jacob S Stevens, Pietro A Canetta, Eric Siddall
Affiliations
Case Reports

Polyuria due to Pressure Natriuresis in Venoarterial Extracorporeal Membrane Oxygenation

Raphael J Rosen et al. ASAIO J. .

Abstract

We report a case of a 40-year-old woman who developed profound polyuria (>25 L urine output) immediately after initiation of venoarterial (VA) extracorporeal membrane oxygenation (ECMO). Investigations into the cause determined the polyuria was due to marked natriuresis (>85 g of sodium excreted in 1 day). This natriuresis persisted despite low cardiac filling pressures and high-negative ECMO venous pressures, suggesting clinical hypovolemia due to pressure natriuresis from locally high pressures at the renal artery due to arterial ECMO inflow. As ECMO flows were decreased, polyuria and natriuresis resolved. To our knowledge, this is the first description of VA-ECMO-associated salt wasting.

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Conflict of interest statement

Disclosure: The authors have no conflicts of interest to report.

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