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Review
. 2022 Jan;237(1):507-522.
doi: 10.1002/jcp.30594. Epub 2021 Oct 1.

The implications of the purinergic signaling throughout pregnancy

Lucas Sagrillo-Fagundes  1 , Thaís Casagrande Paim  1 , Luiza Pretto  1 , Isadora Bertaco  1 , Carla Zanatelli  1 , Cathy Vaillancourt  2 , Márcia R Wink  1
Affiliations
Review

The implications of the purinergic signaling throughout pregnancy

Lucas Sagrillo-Fagundes et al. J Cell Physiol. 2022 Jan.

Abstract

Purinergic signaling is a necessary mechanism to trigger or even amplify cell communication. Its ligands, notably adenosine triphosphate (ATP) and adenosine, modulate specific membrane-bound receptors in virtually all human cells. Regardless of the stage of the pregnancy, cellular communication between maternal, placental, and fetal cells is the paramount mechanism to sustain its optimal status. In this review, we describe the crucial role of purinergic signaling on the regulation of the maternal-fetal trophic exchanges, immune control, and endocrine exchanges throughout pregnancy. The nature of the modulation of both ATP and adenosine on the embryo-maternal interface, going through placental invasion until birth delivery depends on the general maternal-fetal health state and consequently on the selective activation of their specific receptors. In addition, an increasing number of studies have been demonstrating the pivotal role of ATP and adenosine in modulating deleterious effects of suboptimal conditions of pregnancy. Here, we discuss the role of purinergic signaling on the balance that coordinates the embryo-maternal exchanges and a promising therapeutic venue in the context of pregnancy disorders.

Keywords: ATP; Adenosine; embryo-maternal interface; placenta; pregnancy.

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References

REFERENCES

    1. Abrahams, V. M., Tang, Z., Mor, G., & Guller, S. (2020). NLRP3 inflammasome function and pyroptotic cell death in human placental Hofbauer cells. Journal of Reproductive Immunology, 142, 103214.
    1. Acurio, J., Herlitz, K., Troncoso, F., Aguayo, C., Bertoglia, P., & Escudero, C. (2017). Adenosine A2A receptor regulates expression of vascular endothelial growth factor in feto-placental endothelium from normal and late-onset pre-eclamptic pregnancies. Purinergic Signalling, 13(1), 51-60.
    1. Allard, B., Longhi, M. S., Robson, S. C., & Stagg, J. (2017). The ectonucleotidases CD39 and CD73: Novel checkpoint inhibitor targets. Immunological Reviews, 276(1), 121-144.
    1. Altmäe, S., Koel, M., Võsa, U., Adler, P., Suhorutšenko, M., Laisk-Podar, T., Kukushkina, V., Saare, M., Velthut-Meikas, A., Krjutškov, K., Aghajanova, L., Lalitkumar, P. G., Gemzell-Danielsson, K., Giudice, L., Simón, C., & Salumets, A. (2017). Meta-signature of human endometrial receptivity: A meta-analysis and validation study of transcriptomic biomarkers. Scientific Reports, 7(1), 10077.
    1. Amirian, A., Mahani, M. B., & Abdi, F. (2020). Role of interleukin-6 (IL-6) in predicting gestational diabetes mellitus. Obstetrics & Gynecology Science, 63(4), 407-416.

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