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Editorial
. 2021 Nov;12(11):2813-2816.
doi: 10.1007/s13300-021-01155-2. Epub 2021 Oct 1.

An Update to the Article "Efficacy and Side Effect Profile of Different Formulations of Metformin: A Systematic Review and Meta-Analysis"

Catherine Aiken  1 , Jane Tarry-Adkins  2 , Imogen Grant  2 , Rebecca Reynolds  3 , Susan Ozanne  4
Affiliations
Editorial

An Update to the Article "Efficacy and Side Effect Profile of Different Formulations of Metformin: A Systematic Review and Meta-Analysis"

Catherine Aiken et al. Diabetes Ther. 2021 Nov.
No abstract available

Keywords: Diabetes; Drug formulations; Metformin; Therapy.

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Figures

Fig. 1
Fig. 1
The effect of metformin formulation upon gastrointestinal side effects comparing met-XR versus met-IR. This is an updated version of Fig. 5a within our previous publication [2], now including additional data from the study by Fujioka et al. [4] that has not previously been published but was subsequently made available outside of our pre-specified search strategy by kind permission of Merck Healthcare KGaA. The addition of this extra data does not alter the substantive conclusions of the meta-analysis previously presented. There is a lower likelihood of experiencing gastrointestinal side effects with metformin XR than IR (OR 0.76, CI 0.58–1.00), but this does not reach the pre-specified threshold for significance (p = 0.05)
See this image and copyright information in PMC

References

    1. NHS Digital. Increase in prescriptions for diabetes exceeds rise in overall prescribing. https://digital.nhs.uk/news-and-events/news-archive/2017-news-archive/in.... Accessed 1 July 2021.
    1. Tarry-Adkins JL, Grant ID, Ozanne SE, Reynolds RM, Aiken CE. Efficacy and side effect profile of different formulations of metformin: a systematic review and meta-analysis. Diabetes Ther. 2021 doi: 10.1007/s13300-021-01058-2. - DOI - PMC - PubMed
    1. Dujic T, Zhou K, Donnelly LA, Tavendale R, Palmer CN, Pearson ER. Association of organic cation transporter 1 with intolerance to metformin in type 2 diabetes: a GoDARTS study. Diabetes. 2015;64(5):1786–1793. doi: 10.2337/db14-1388. - DOI - PMC - PubMed
    1. Fujioka K, Pans M, Joyal S. Glycemic control in patients with type 2 diabetes mellitus switched from twice-daily immediate-release metformin to a once-daily extended-release formulation. Clin Ther. 2003;25(2):515–529. doi: 10.1016/S0149-2918(03)80093-0. - DOI - PubMed
    1. Agency for Healthcare Research and Quality Rockville MD. Medical expenditure panel survey (MEPS). 2018. https://www.ahqr.gov/data/meps.html. Accessed 1 July 2021.

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