Can we teach a tired cell new tricks?

Affiliations

¹ Children's Hospital of Philadelphia, Division of Allergy Immunology, Department of Pediatrics and Department of Microbiology Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104 USA. Email: henricksons@chop.edu.

Comment

Sarah E Henrickson. Sci Immunol. 2021 Oct.

. 2021 Oct;6(64):eabm5115.

doi: 10.1126/sciimmunol.abm5115. Epub 2021 Oct 1.

¹ Children's Hospital of Philadelphia, Division of Allergy Immunology, Department of Pediatrics and Department of Microbiology Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104 USA. Email: henricksons@chop.edu.

Abstract

PD-1⁺ viral specific CD8 T cells with proliferative capacity are identified in human head and neck squamous cell carcinoma.

Functional HPV-specific PD-1⁺ stem-like CD8 T cells in head and neck cancer.
Eberhardt CS, Kissick HT, Patel MR, Cardenas MA, Prokhnevska N, Obeng RC, Nasti TH, Griffith CC, Im SJ, Wang X, Shin DM, Carrington M, Chen ZG, Sidney J, Sette A, Saba NF, Wieland A, Ahmed R. Eberhardt CS, et al. Nature. 2021 Sep;597(7875):279-284. doi: 10.1038/s41586-021-03862-z. Epub 2021 Sep 1. Nature. 2021. PMID: 34471285 Free PMC article.