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. 2021 Oct 11;39(10):1305-1307.
doi: 10.1016/j.ccell.2021.09.006. Epub 2021 Sep 30.

Dissecting bulk transcriptomes of diffuse large B cell lymphoma

Dylan R McNally  1 , Olivier Elemento  1 , Ari Melnick  2
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Dissecting bulk transcriptomes of diffuse large B cell lymphoma

Dylan R McNally et al. Cancer Cell. .
Free article

Abstract

Diffuse large B cell lymphoma (DLBCL) is a markedly phenotypically heterogenous disease, frequently assessed using bulk genomic techniques that blur the intrinsic heterogeneity of each tumor. In this issue of Cancer Cell, Steen et al. have utilized a computational framework called EcoTyper to skillfully dissect bulk transcriptomic tumor profiles into different cell type components in an unsupervised manner.

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Conflict of interest statement

Declaration of interests A.M. has consulted for Epizyme, Constellation, Daiichi Sankyo, AstraZeneca, BMS, Janssen, and ExoTherapeutics. A.M. has research funding from Epizyme, Janssen, Daiichi Sankyo, and AstraZeneca. A.M. is on the advisory board of KDAC. O.E. is supported by Janssen, Johnson and Johnson, Volastra Therapeutics, AstraZeneca, and Eli Lilly research grants. O.E. is scientific advisor and equity holder in Freenome, Owkin, Volastra Therapeutics, and One Three Biotech.

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