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. 2021 Sep 30;184(20):5082-5084.
doi: 10.1016/j.cell.2021.08.033.

Microglia esprit de corps: Sharing the burden of eliminating toxic aggregates

Yun Chen  1 , Marco Colonna  2
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Microglia esprit de corps: Sharing the burden of eliminating toxic aggregates

Yun Chen et al. Cell. .
Free article

Abstract

Microglia play critical roles in the defense against neurodegenerative diseases. In this issue of Cell, Scheiblich et al. focus on microglia that ingest toxic aggregates of α-synuclein, finding that α-synuclein-replete microglia exchange aggregates for healthy mitochondria via nanotube connections to unaffected microglia. This communication enables a shared approach to aggregates disposal while preserving the health of the microglial population.

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