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. 2022 Mar;204(Pt B):112141.
doi: 10.1016/j.envres.2021.112141. Epub 2021 Sep 28.

Origin of COVID-19: Dismissing the Mojiang mine theory and the laboratory accident narrative

Affiliations

Origin of COVID-19: Dismissing the Mojiang mine theory and the laboratory accident narrative

Roger Frutos et al. Environ Res. 2022 Mar.

Abstract

The origin of SARS-CoV-2 is still the subject of a controversial debate. The natural origin theory is confronted to the laboratory leak theory. The latter is composite and comprises contradictory theories, one being the leak of a naturally occurring virus and the other the leak of a genetically engineered virus. The laboratory leak theory is essentially based on a publication by Rahalkar and Bahulikar in 2020 linking SARS-CoV-2 to the Mojiang mine incident in 2012 during which six miners fell sick and three died. We analyzed the clinical reports. The diagnosis is not that of COVID-19 or SARS. SARS-CoV-2 was not present in the Mojiang mine. We also bring arguments against the laboratory leak narrative.

Keywords: COVID-19; Clinical diagnosis; Mojiang mine; Origin of SARS-CoV-2.

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Conflict of interest statement

The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.

Figures

Fig. 1
Fig. 1
Phylogenetic analysis of the spike genes used for genetic engineering. The genes used for genetic engineering are those described in the NIH Grant 1RO1 Al 110,964–01 (https://www.documentcloud.org/documents/21055989-understanding-risk-bat-coronavirus-emergence-grant-notice), i.e. WV1, WV16, SHC014 and Rs4231. The spike protein gene of MERS-CoV was used as outgroup to root the tree. Sequences were aligned using MUSCLE in the SeaView package (Gouy et al., 2010). The phylogenetic tree was built using the maximum likelihood method with GTR-G-I evolutionary model and 500 bootstrap repeats.

References

    1. Bloom J.D., Chan Y.A., Baric R.S., Bjorkman P.J., Cobey S., Deverman B.E., et al. Investigate the origin of COVID-19. Science. 2021;372:694. - PMC - PubMed
    1. Brill-Edwards P., Lee A. D-dimer testing in the diagnosis of acute venous thromboembolism. Thromb. Haemostasis. 1999;82:688–694. - PubMed
    1. Cohen J. Wuhan coronavirus hunter Shi Zhengli speaks out. Science. 2020;369:487–488. - PubMed
    1. Frutos R., Gavotte L., Devaux C.A. Understanding the origin of COVID-19 requires to change the paradigm on zoonotic emergence from the spillover model to the circulation model. Infect. Genet. Evol. 2021:104812. - PMC - PubMed
    1. Ge X.Y., Wang N., Zhang W., Hu B., Li B., Zhang Y.Z., et al. Coexistence of multiple coronaviruses in several bat colonies in an abandoned mineshaft. Virol. Sin. 2016;31:31–40. - PMC - PubMed