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Review
. 2021 Nov:157:428-440.
doi: 10.1016/j.ejca.2021.08.033. Epub 2021 Sep 28.

Therapeutic drug monitoring in oncology: International Association of Therapeutic Drug Monitoring and Clinical Toxicology consensus guidelines for imatinib therapy

William A Clarke  1 , Etienne Chatelut  2 , Alan K Fotoohi  3 , Richard A Larson  4 , Jennifer H Martin  5 , Ron H J Mathijssen  6 , Salvatore J Salamone  7
Affiliations
Review

Therapeutic drug monitoring in oncology: International Association of Therapeutic Drug Monitoring and Clinical Toxicology consensus guidelines for imatinib therapy

William A Clarke et al. Eur J Cancer. 2021 Nov.

Abstract

Although therapeutic drug monitoring (TDM) is an important tool in guiding drug dosing for other areas of medicine including infectious diseases, cardiology, psychiatry and transplant medicine, it has not gained wide acceptance in oncology. For imatinib and other tyrosine kinase inhibitors, a flat dosing approach is utilised for management of oral chemotherapy. There are many published studies examining the correlation of blood concentrations with clinical effects of imatinib. The International Association of Therapeutic Drug Monitoring and Clinical Toxicology (IATDMCT) determined that there was a need to examine the published literature regarding utility of TDM in imatinib therapy and to develop consensus guidelines for TDM based on the available data. This article summarises the scientific evidence regarding TDM of imatinib, as well as the consensus guidelines developed by the IATDMCT.

Keywords: Gastrointestinal stromal tumour (GIST); Imatinib; Precision medicine, Leukaemia; Therapeutic drug monitoring.

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Conflict of interest statement

Conflict of interest statement W.A.C., E.C., A.K.F. and J.H.M. have no declared conflicts of interest in relation to this work. RJHM has no conflicts of interest in relation to this work. However, his institution has received research funding for investigator-initiated research from Astellas, Bayer, Boehringer Ingelheim, Cristal Therapeutics, Novartis, PamGene, Pfizer, Roche, Sanofi and Servier. R.A.L. has acted as a consultant or advisor to Amgen, Ariad/Takeda, Astellas, Celgene/Bristol Myers Squibb, CVS/Caremark, Epizyme, MorphoSys and Novartis and has received clinical research support to his institution from Astellas, Celgene, Cellectis, Daiichi Sankyo, Forty Seven/Gilead, Novartis and Rafael Pharmaceuticals and royalties from UpToDate. S.J.S. is the founder and CEO of Saladax Biomedical, Inc.

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