Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Review
. 2021 Sep;34 Suppl 1(Suppl1):29-31.
doi: 10.37201/req/s01.08.2021. Epub 2021 Sep 30.

Ceftaroline

A Soriano  1
Affiliations
Review

Ceftaroline

A Soriano. Rev Esp Quimioter. 2021 Sep.

Abstract

Community-acquired pneumonia (CAP) is one of the leading causes of admission to emergency departments. Ceftaroline is a fifth-generation cephalosporin with a potent In vitro activity against Streptococcus pneumoniae, Haemophilus influenzae and Staphylococcus aureus, the three most important pathogens causing CAP. Three randomized and double-blind clinical trials compared the efficacy of ceftaroline versus ceftriaxone in patients with CAP and the results of each trial and a meta-analysis, concluded the superiority of ceftaroline in terms of clinical success. In particular, the major difference was observed among patients with CAP caused by S. aureus. Accordingly, ceftaroline has been included as a first-line option in the recent clinical guidelines for the management of CAP.

PubMed Disclaimer

Conflict of interest statement

AS has received honoraria for lectures and advisory boards from Pfizer, MSD, Shionogi, Menarini, Angelini and Gilead.

References

    1. Metlay JP, Waterer GW, Long AC, Anzueto A, Brozek J, Crothers K, et al. . Diagnosis and Treatment of Adults with Community-acquired Pneumonia. An Official Clinical Practice Guideline of the American Thoracic Society and Infectious Diseases Society of America. Am J Respir Crit Care Med. 2019;200(7):e45-e67. doi: 10.1164/rccm.201908-1581ST. - DOI - PMC - PubMed
    1. Saravolatz LD, Stein GE, Johnson LB. Ceftaroline: A Novel Cephalosporin with Activity against Methicillin-resistant Staphylococcus aureus. Clin Infect Dis. 2011;52(9):1156-63. doi: 10.1093/cid/cir147 - DOI - PubMed
    1. Sader HS, Mendes RE, Le J, Denys G, Flamm RK, Jones RN. Antimicrobial Susceptibility of Streptococcus pneumoniae from North America, Europe, Latin America, and the Asia-Pacific Region: Results From 20 Years of the SENTRY Antimicrobial Surveillance Program (1997-2016). Open Forum Infect Dis. 2019;6(Suppl 1):S14-S23. doi: 10.1093/ofid/ofy263. - DOI - PMC - PubMed
    1. Smith JR, Barber KE, Raut A, Aboutaleb M, Sakoulas G, Rybak MJ. β-Lactam combinations with daptomycin provide synergy against vancomycin-resistant Enterococcus faecalis and Enterococcus faecium. J Antimicrob Chemother. 2015;70(6):1738-43. doi: 10.1093/jac/dkv007. - DOI - PMC - PubMed
    1. Cristinacce A, Wright JG, Stone GG, Hammond J, McFadyen L, Raber S. A Retrospective Analysis of Probability of Target Attainment in Community-Acquired Pneumonia: Ceftaroline Fosamil Versus Comparators. Infect Dis Ther. 2019;8(2):185-198. doi: 10.1007/s40121-019-0243-4. - DOI - PMC - PubMed

MeSH terms