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Clinical Trial
. 2021 Dec 1;32(12):3020-3023.
doi: 10.1681/ASN.2021050659. Epub 2021 Dec 1.

Second Wave Antibodies in Autoimmune Renal Diseases: The Case of Lupus Nephritis

Andrea Angeletti  1   2 , Maurizio Bruschi  1 , Gabriella Moroni  3 , Renato Alberto Sinico  4 , Franco Franceschini  5 , Micaela Fredi  5 , Augusto Vaglio  6   7 , Lorenzo Cavagna  8 , Andrea Petretto  9 , Federico Pratesi  10 , Paola Migliorini  10 , Francesco Locatelli  7 , Giulia Pazzola  11 , Giampaola Pesce  12 , Marcello Bagnasco  12 , Angelo Manfredi  13 , Giuseppe A Ramirez  13 , Pasquale Esposito  14 , Giuseppe Murdaca  15 , Simone Negrini  15 , Leda Cipriani  16 , Barbara Trezzi  4 , Giacomo Emmi  17 , Ilaria Cavazzana  5 , Valentina Binda  3 , Matteo d'Alessandro  2 , Paride Fenaroli  18 , Isabella Pisani  18 , Giacomo Garibotto  16 , Carlomaurizio Montecucco  8 , Domenico Santoro  19 , Francesco Scolari  20 , Stefano Volpi  21 , Marta Mosca  22 , Angela Tincani  5 , Giovanni Candiano  1 , Marco Prunotto  23 , Enrico Verrina  2 , Angelo Ravelli  21 , Gian Marco Ghiggeri  1   2
Affiliations
Clinical Trial

Second Wave Antibodies in Autoimmune Renal Diseases: The Case of Lupus Nephritis

Andrea Angeletti et al. J Am Soc Nephrol. .

Abstract

Clinical Trial registry name and registration number: Zeus study, NCT02403115.

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Figures

Figure 1.
Figure 1.
Circulating levels of anti-SOD2 IgG2. (A) Cross-sectional study. Circulating levels of anti-SOD2 IgG2 were determined in two cohorts of patients with SLE with (459) and without (573) LN recruited at different times from the beginning of symptoms. One hundred eighty-two normal controls were studied as well. Clinical characteristics of all patients are reported in Supplemental Table 1. (B and C) Prospective study. Ninety-one LN patients recruited at the time of the diagnosis were prospectively followed for 36 months. Anti-SOD2 IgG2 (B) and anti-dsDNA IgG2 (C) levels were determined every 6 months in the first year and then every 12 months. In both cases, levels were calculated as relative intensity value (RU/ml) given the absence of WHO international standards. The line in (C) indicates normal limits for anti-dsDNA IgG2. **P<0.001 versus healthy, SLE and LN any other time point; *P<0.001 versus healthy, SLE any other time point; °P<0,001 versus T0. dsDNA, double-strain DNA.
See this image and copyright information in PMC

References

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