Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 1986 Jul;83(13):4641-5.
doi: 10.1073/pnas.83.13.4641.

Exogenous glutathione protects intestinal epithelial cells from oxidative injury

L H Lash, T M Hagen, D P Jones

Exogenous glutathione protects intestinal epithelial cells from oxidative injury

L H Lash et al. Proc Natl Acad Sci U S A. 1986 Jul.

Abstract

Exogenous GSH provided rat small-intestinal epithelial cells with significant protection against injury induced by t-butyl hydroperoxide or menadione. This protection was found to be dependent upon uptake of intact GSH. Uptake of GSH occurred by a Na+-dependent electrogenic system found in the basolateral membrane. Thus, rat small-intestinal epithelial cells can utilize plasma GSH to support intracellular detoxication systems that function in protection against chemically induced injury.

PubMed Disclaimer

References

    1. Anal Biochem. 1976 May 7;72:248-54 - PubMed
    1. Arch Biochem Biophys. 1985 Aug 1;240(2):583-92 - PubMed
    1. J Biol Chem. 1979 Aug 25;254(16):7558-60 - PubMed
    1. Med Biol. 1979 Oct;57(5):287-93 - PubMed
    1. Biochem J. 1980 Jan 15;186(1):177-81 - PubMed

Publication types

LinkOut - more resources