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Comment
. 2021 Nov:232:108870.
doi: 10.1016/j.clim.2021.108870. Epub 2021 Sep 30.

Commensal bacterial metabolites may strengthen the effect of anti-IL6 treatment for COVID-19

Jiezhong Chen  1 , Luis Vitetta  2
Affiliations
Comment

Commensal bacterial metabolites may strengthen the effect of anti-IL6 treatment for COVID-19

Jiezhong Chen et al. Clin Immunol. 2021 Nov.
No abstract available

Keywords: Butyrate; COVID-19; Regulatory T cells; Tocilizumab.

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References

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    1. Corominas H., Castellvi I., Pomar V., et al. Effectiveness and safety of intravenous tocilizumab to treat COVID-19-associated hyperinflammatory syndrome: Covizumab-6 observational cohort. Clin. Immunol. 2021;223:108631. - PMC - PubMed
    1. Luo M., Liu J., Jiang W., et al. IL-6 and CD8+ T cell counts combined are an early predictor of in-hospital mortality of patients with COVID-19. JCI Insight. 2020;5(13) - PMC - PubMed
    1. Bultman S.J. Bacterial butyrate prevents atherosclerosis. Nat. Microbiol. 2018;3:1332–1333. - PubMed
    1. Chen J., Vitetta L. The role of butyrate in attenuating pathobiont-induced hyperinflammation. Immune Netw. 2020;20(2) - PMC - PubMed

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