Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2022 Feb;74(1):87-96.
doi: 10.1007/s13304-021-01161-w. Epub 2021 Oct 3.

Is minimally invasive liver surgery a reasonable option in recurrent HCC? A snapshot from the I Go MILS registry

Giovanni Battista Levi Sandri  1 , Marco Colasanti  2 , Luca Aldrighetti  3 , Alfredo Guglielmi  4 , Umberto Cillo  5 , Vincenzo Mazzaferro  6   7 , Raffaele Dalla Valle  8 , Luciano De Carlis  9   10 , Salvatore Gruttadauria  11   12 , Fabrizio Di Benedetto  13 , Alessandro Ferrero  14 , Giuseppe Maria Ettorre  2 ; I Go MILS Group on HCC
Collaborators, Affiliations
Free article

Is minimally invasive liver surgery a reasonable option in recurrent HCC? A snapshot from the I Go MILS registry

Giovanni Battista Levi Sandri et al. Updates Surg. 2022 Feb.
Free article

Erratum in

Abstract

Laparoscopic liver resection (LLR) for Hepatocellular carcinoma (HCC) is a safe procedure. Repeat surgery is more often required, and the role of minimally invasive liver surgery (MILS) is not yet clearly defined. The present study analyzes data compiled by the Italian Group of Minimally Invasive Liver Surgery (IGoMILS) on LLR. To compare repeated LLR with the first LLR for HCC is the primary endpoint. The secondary endpoint was to evaluate the outcome of repeat LLR in the case of primary open versus primary MILS surgery. The data cohort is divided into two groups. Group 1: first liver resection and Group 2: Repeat LLR. To compare the two groups a 3:1 Propensity Score Matching is performed to analyze open versus MILS primary resection. Fifty-two centers were involved in the present study, and 1054 patients were enrolled. 80 patients underwent to a repeat LLR. The type of resection was different, with more major resections in the group 1 before matching the two groups. After propensity score matching 3:1, each group consisted of 222 and 74 patients. No difference between the two groups was observed. In the subgroup analysis, in 44 patients the first resection was performed by an open approach. The other 36 patients were resected with a MILS approach. We found no difference between these two subgroups of patients. The present study in repeat MILS for HCC using the IGoMILS Registry has observed the feasibility and safety of the MILS procedure.

Keywords: IGoMILS; Laparoscopic HCC; Laparoscopic indications; Laparoscopic liver resection; Minimally invasive; Recurrence; Redo surgery; Robotic.

PubMed Disclaimer

References

    1. Levi Sandri GB, de Werra E, Mascianà G, Colasanti M, Santoro R, D’Andrea V et al (2016) Laparoscopic and robotic approach for hepatocellular carcinoma-state of the art. Hepatobiliary Surg Nutr 5(6):478–484. https://doi.org/10.21037/hbsn.2016.05.05 - DOI
    1. Cipriani F, Fantini C, Ratti F, Lauro R, Tranchart H, Halls M et al (2018) Laparoscopic liver resections for hepatocellular carcinoma. Can we extend the surgical indication in cirrhotic patients? Surg Endosc 32(2):617–626. https://doi.org/10.1007/s00464-017-5711-x - DOI
    1. Berardi G, Morise Z, Sposito C, Igarashi K, Panetta V, Simonelli I et al (2020) Development of a nomogram to predict outcome after liver resection for hepatocellular carcinoma in Child-Pugh B cirrhosis. J Hepatol 72(1):75–84. https://doi.org/10.1016/j.jhep.2019.08.032 - DOI
    1. Ettorre GM, Levi Sandri GB, Santoro R, Vennarecci G, Lepiane P, Colasanti M et al (2015) Laparoscopic liver resection for hepatocellular carcinoma in cirrhotic patients: single center experience of 90 cases. Hepatobiliary Surg Nutr 4(5):320–324. https://doi.org/10.3978/j.issn.2304-3881.2015.06.13 - PubMed - PMC
    1. Levi Sandri GB, Ettorre GM, Aldrighetti L, Cillo U, Dalla Valle R, Guglielmi A et al (2019) Laparoscopic liver resection of hepatocellular carcinoma located in unfavorable segments: a propensity score-matched analysis from the I Go MILS (Italian Group of Minimally Invasive Liver Surgery) Registry. Surg Endosc 33(5):1451–1458. https://doi.org/10.1007/s00464-018-6426-3 - DOI