Isolated Diastolic Hypertension in the IDACO Study: An Age-Stratified Analysis Using 24-Hour Ambulatory Blood Pressure Measurements

John W McEvoy¹, Wen-Yi Yang², Lutgarde Thijs³, Zhen-Yu Zhang³, Jesus D Melgarejo³, José Boggia⁴, Tine W Hansen⁵, Kei Asayama^{3

6

7}, Takayoshi Ohkubo^{6

7}, Eamon Dolan⁸, Katarzyna Stolarz-Skrzypek⁹, Sofia Malyutina¹⁰, Edoardo Casiglia¹¹, Lars Lind¹², Jan Filipovský¹³, Gladys E Maestre^{14

15}, Yan Li¹⁶, Ji-Guang Wang¹⁶, Yutaka Imai⁶, Kalina Kawecka-Jaszcz⁹, Edgardo Sandoya¹⁷, Krzysztof Narkiewicz¹⁸, Eoin O'Brien¹⁹, Thomas Vanassche²⁰, Jan A Staessen^{21

22}; International Database on Ambulatory Blood Pressure in Relation to Cardiovascular Outcomes (IDACO) Investigators

Affiliations

¹ National University of Ireland Galway, School of Medicine, and National Institute for Prevention and Cardiovascular Health, Ireland (J.W.M.).
² Department of Cardiology, Shanghai General Hospital (W.-Y.Y.), Shanghai Jiao Tong University School of Medicine, China.
³ Research Unit Hypertension and Cardiovascular Epidemiology, KU Leuven Department of Cardiovascular Sciences (Z.-Y.Z., L.T., J.D.M., K.A.), University of Leuven, Belgium.
⁴ Centro de Nefrología and Departamento de Fisiopatología, Hospital de Clínicas, Universidad de la República, Montevideo, Uruguay (J.B.).
⁵ The Steno Diabetes Center Copenhagen, Gentofte, and Center for Health, Capital Region of Denmark, Copenhagen (T.W.H.).
⁶ Tohoku Institute for Management of Blood Pressure, Sendai, Japan (K.A., T.O., Y.I.).
⁷ Department of Hygiene and Public Health, Teikyo University School of Medicine, Tokyo, Japan (K.A., T.O.).
⁸ Stroke and Hypertension Unit, Connolly Hospital, Geriatric Medicine, Dublin, Ireland (E.D.).
⁹ The First Department of Cardiology, Interventional Electrocardiology and Hypertension, Jagiellonian University Medical College, Krakow, Poland (K.S.-S., K.K.-J.).
¹⁰ Institute of Internal and Preventive Medicine and Institute of Cytology and Genetics, Siberian Branch of the Russian Academy of Sciences, Novosibirsk, Russian Federation (S.M.).
¹¹ Department of Medicine, University of Padua, Italy (E.C.).
¹² Section of Geriatrics, Department of Public Health and Caring Sciences, Uppsala University, Sweden (L.L.).
¹³ Faculty of Medicine, Charles University, Pilsen, Czech Republic (J.F.).
¹⁴ Laboratorio de Neurociencias and Instituto Cardiovascular, Universidad del Zulia, Maracaibo, Venezuela (G.E.M.).
¹⁵ Department of Biomedical Sciences, Division of Neuroscience and Department of Human Genetics, University of Texas Rio Grande Valley School of Medicine, Brownsville (G.E.M.).
¹⁶ Center for Epidemiological Studies and Clinical Trials and Center for Vascular Evaluation, Shanghai Institute of Hypertension, Ruijin Hospital (Y.L., J.-G.W.), Shanghai Jiao Tong University School of Medicine, China.
¹⁷ Asociación Española Primera de Socorros Mutuos, Montevideo, Uruguay (E.S.).
¹⁸ Hypertension Unit, Department of Hypertension and Diabetology, Medical University of Gdansk, Poland (K.N.).
¹⁹ Conway Institute of Biomolecular and Biomedical Research, University College Dublin, Ireland (E.O.).
²⁰ Centre for Molecular and Vascular Biology, KU Leuven Department of Cardiovascular Sciences (T.V.), University of Leuven, Belgium.
²¹ Biomedical Sciences Group, Faculty of Medicine (J.A.S.), University of Leuven, Belgium.
²² Research Institute Alliance for the Promotion of Preventive Medicine, Mecehelen, Belgium (J.A.S).

PMID: 34601965
PMCID: PMC8516806
DOI: 10.1161/HYPERTENSIONAHA.121.17766

Isolated Diastolic Hypertension in the IDACO Study: An Age-Stratified Analysis Using 24-Hour Ambulatory Blood Pressure Measurements

John W McEvoy et al. Hypertension. 2021 Nov.

. 2021 Nov;78(5):1222-1231.

doi: 10.1161/HYPERTENSIONAHA.121.17766. Epub 2021 Oct 4.

Authors

Affiliations

¹ National University of Ireland Galway, School of Medicine, and National Institute for Prevention and Cardiovascular Health, Ireland (J.W.M.).
² Department of Cardiology, Shanghai General Hospital (W.-Y.Y.), Shanghai Jiao Tong University School of Medicine, China.
³ Research Unit Hypertension and Cardiovascular Epidemiology, KU Leuven Department of Cardiovascular Sciences (Z.-Y.Z., L.T., J.D.M., K.A.), University of Leuven, Belgium.
⁴ Centro de Nefrología and Departamento de Fisiopatología, Hospital de Clínicas, Universidad de la República, Montevideo, Uruguay (J.B.).
⁵ The Steno Diabetes Center Copenhagen, Gentofte, and Center for Health, Capital Region of Denmark, Copenhagen (T.W.H.).
⁶ Tohoku Institute for Management of Blood Pressure, Sendai, Japan (K.A., T.O., Y.I.).
⁷ Department of Hygiene and Public Health, Teikyo University School of Medicine, Tokyo, Japan (K.A., T.O.).
⁸ Stroke and Hypertension Unit, Connolly Hospital, Geriatric Medicine, Dublin, Ireland (E.D.).
⁹ The First Department of Cardiology, Interventional Electrocardiology and Hypertension, Jagiellonian University Medical College, Krakow, Poland (K.S.-S., K.K.-J.).
¹⁰ Institute of Internal and Preventive Medicine and Institute of Cytology and Genetics, Siberian Branch of the Russian Academy of Sciences, Novosibirsk, Russian Federation (S.M.).
¹¹ Department of Medicine, University of Padua, Italy (E.C.).
¹² Section of Geriatrics, Department of Public Health and Caring Sciences, Uppsala University, Sweden (L.L.).
¹³ Faculty of Medicine, Charles University, Pilsen, Czech Republic (J.F.).
¹⁴ Laboratorio de Neurociencias and Instituto Cardiovascular, Universidad del Zulia, Maracaibo, Venezuela (G.E.M.).
¹⁵ Department of Biomedical Sciences, Division of Neuroscience and Department of Human Genetics, University of Texas Rio Grande Valley School of Medicine, Brownsville (G.E.M.).
¹⁶ Center for Epidemiological Studies and Clinical Trials and Center for Vascular Evaluation, Shanghai Institute of Hypertension, Ruijin Hospital (Y.L., J.-G.W.), Shanghai Jiao Tong University School of Medicine, China.
¹⁷ Asociación Española Primera de Socorros Mutuos, Montevideo, Uruguay (E.S.).
¹⁸ Hypertension Unit, Department of Hypertension and Diabetology, Medical University of Gdansk, Poland (K.N.).
¹⁹ Conway Institute of Biomolecular and Biomedical Research, University College Dublin, Ireland (E.O.).
²⁰ Centre for Molecular and Vascular Biology, KU Leuven Department of Cardiovascular Sciences (T.V.), University of Leuven, Belgium.
²¹ Biomedical Sciences Group, Faculty of Medicine (J.A.S.), University of Leuven, Belgium.
²² Research Institute Alliance for the Promotion of Preventive Medicine, Mecehelen, Belgium (J.A.S).

PMID: 34601965
PMCID: PMC8516806
DOI: 10.1161/HYPERTENSIONAHA.121.17766

Abstract

[Figure: see text].

Keywords: blood pressure; hypertension; morbidity; mortality; risk.

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Figures

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References

1. Staessen JA, Byttebier G, Buntinx F, Celis H, O’Brien ET, Fagard R; for the Ambulatory Blood Pressure Monitoring and Treatment of Hypertension Investigators. Antihypertensive treatment based on conventional or ambulatory blood pressure measurement. A randomized controlled trial. JAMA. 1997;278:1065–1072. doi: 10.1001/jama.1997.03550130039034 - PubMed
1. Staessen JA, Thijs L, Fagard R, O’Brien ET, Clement D, de Leeuw PW, Mancia G, Nachev C, Palatini P, Parati G, et al. . Predicting cardiovascular risk using conventional vs ambulatory blood pressure in older patients with systolic hypertension. Systolic Hypertension in Europe Trial Investigators. JAMA. 1999;282:539–546. doi: 10.1001/jama.282.6.539 - PubMed
1. Yang WY, Melgarejo JD, Thijs L, Zhang ZY, Boggia J, Wei FF, Hansen TW, Asayama K, Ohkubo T, Jeppesen J, et al. ; International Database on Ambulatory Blood Pressure in Relation to Cardiovascular Outcomes (IDACO) Investigators. Association of office and ambulatory blood pressure with mortality and cardiovascular outcomes. JAMA. 2019;322:409–420. doi: 10.1001/jama.2019.9811 - PMC - PubMed
1. Flint AC, Conell C, Ren X, Banki NM, Chan SL, Rao VA, Melles RB, Bhatt DL. Effect of systolic and diastolic blood pressure on cardiovascular outcomes. N Engl J Med. 2019;381:243–251. doi: 10.1056/NEJMoa1803180 - PubMed
1. McEvoy JW, Daya N, Rahman F, Hoogeveen RC, Blumenthal RS, Shah AM, Ballantyne CM, Coresh J, Selvin E. Association of isolated diastolic hypertension as defined by the 2017 ACC/AHA blood pressure guideline with incident cardiovascular outcomes. JAMA. 2020;323:329–338. doi: 10.1001/jama.2019.21402 - PMC - PubMed

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Isolated Diastolic Hypertension in the IDACO Study: An Age-Stratified Analysis Using 24-Hour Ambulatory Blood Pressure Measurements

Affiliations

Isolated Diastolic Hypertension in the IDACO Study: An Age-Stratified Analysis Using 24-Hour Ambulatory Blood Pressure Measurements

Authors

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Abstract

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Medical