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. 2021 Nov;78(5):1278-1286.
doi: 10.1161/HYPERTENSIONAHA.121.17702. Epub 2021 Oct 4.

Aortic Root Diameter and Arterial Stiffness: Conjoint Relations to the Incidence of Cardiovascular Disease in the Framingham Heart Study

Ramachandran S Vasan  1   2   3 , Rebecca J Song  3 , Vanessa Xanthakis  1   2   4 , Gary F Mitchell  5
Affiliations

Aortic Root Diameter and Arterial Stiffness: Conjoint Relations to the Incidence of Cardiovascular Disease in the Framingham Heart Study

Ramachandran S Vasan et al. Hypertension. 2021 Nov.

Abstract

[Figure: see text].

Keywords: aorta; blood pressure; cardiovascular disease; carotid-femoral pulse wave velocity; incidence.

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Conflict of interest statement

Disclosures

Gary F. Mitchell is the owner of Cardiovascular Engineering, Inc., a company that designs and manufactures devices that measure vascular stiffness. The company uses these devices in clinical trials that evaluate the effects of diseases and interventions on vascular stiffness. He also reports receiving grants from the National Institutes of Health and Novartis and consulting fees from Novartis, Bayer, Merck, and Servier. The remaining authors report no conflicts.

Figures

Figure 1.
Figure 1.
Sex-specific trajectories of predicted aortic root diameter from regression models. Aortic root grouping was optimized using residuals from the regression models and by assigning participants to the trajectory group for which their posterior probability was the highest according to the following criteria: the average posterior probability of group membership among individuals assigned to that group ≥0.7 for all possible groups; the odds of correct classification >5 for all groups; reasonably close agreement between the probability of membership in group and proportion of the sample assigned to that group; and narrow CI around the probability of group membership.
Figure 2.
Figure 2.
Sex-specific cumulative incidence of cardiovascular disease by cross-classified groups of aortic root trajectory and carotid-femoral pulse wave velocity. CVD, cardiovascular disease; AoR, aortic root; CFPWV, pulse wave velocity.
See this image and copyright information in PMC

References

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