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. 2021 Oct;71(5):510-521.
doi: 10.1007/s13224-020-01410-9. Epub 2021 May 8.

MOTHER Study: A M ulticenter O bservational, Retrospective S t udy to Determine Coorelation Between Physical C H aracteristics and Ovarian R E serve Markers in Sub-fe R tile Women

Charmila Ayyavoo  1 , Asha Baxi  2 , Gorakh Mandrupkar  3 , Sonia Malik  4 , Jayam Kannan  5 , Deepak Goenka  6 , Nagesh Kumar  7 , Monica Singh  8 , Sharda Kulkarni  9 , Kanchan Murarka Agarwal  6 , Sonam Baxi  2
Affiliations

MOTHER Study: A M ulticenter O bservational, Retrospective S t udy to Determine Coorelation Between Physical C H aracteristics and Ovarian R E serve Markers in Sub-fe R tile Women

Charmila Ayyavoo et al. J Obstet Gynaecol India. 2021 Oct.

Abstract

Background: The physical characteristics which are known to affect the ovarian reserve are age, body mass index (BMI), occupational exposures, age at menarche and menstrual cycle length. A correlation between different physical characteristics and the ovarian reserve will help to identify areas which need to be tackled to increase the chances of fertility of women in India.

Methods: In this retrospective, observational study, namely the MOTHER Study, data of women between 18 and 45 years of age, attending the selected fertility centers across different states in India were taken for evaluation. Demographic information along with information on factors potentially related to fertility like age of menarche, menstrual cycle length and occupational factors were collected by review of medical records at screening visit. Most recent AMH assay and antral follicle count (AFC) where the subject has not taken any contraceptives 12 months prior to the test were collected.

Results: Age of woman, years of marriage, years of infertility and smoking have shown effect on ovarian reserve testing like AMH and AFC. The other physical characteristics which were evaluated and considered to affect the ovarian reserve like body mass index BMI, occupational exposures, age at menarche and menstrual cycle length have not shown statistically significant correlation.

Conclusion: Age of woman and years of infertility are inversely proportional to ovarian reserve markers, namely AMH and AFC. Addictions like smoking and alcohol affect ovarian reserve.

Keywords: AFC; AMH; Age of woman; Infertility; Ovarian reserve.

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Conflict of interest statement

Conflict of interestThe authors declare that they have no conflict of interest.

References

    1. Roudebush WE, Kivens WJ, Mattke JM. Biomarker of ovarian reserve. Biomark Insights. 2008;3:259–268. doi: 10.4137/BMI.S537. - DOI - PMC - PubMed
    1. Jaiswar SP, Natu SM, Sankhwar PL, et al. Prediction of poor ovarian response by biochemical and biophysical markers: a logistic regression model. J ObstetGynecol India. 2015;65(6):411–416. doi: 10.1007/s13224-014-0639-8. - DOI - PMC - PubMed
    1. Practice Committee of the American Society for Reproductive Medicine: Testing and Interpreting Measures of Ovarian Reserve: A Committee Opinion. Fertility and Sterility 2015; 103(3): 0015–0282 - PubMed
    1. Durlinger A. Regulation of ovarian function: the role of anti-mullerian hormone. Reproduction. 2002;124(5):601–9. doi: 10.1530/rep.0.1240601. - DOI - PubMed
    1. Fanchin R. High reproducibility of serum anti-mullerian hormone measurements suggests a multi-staged follicular secretion and strengthens its role in the assessment of ovarian follicular status. Hum Reprod. 2005;20(4):923–927. doi: 10.1093/humrep/deh688. - DOI - PubMed

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