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. 2021 Sep;13(3):219-223.
doi: 10.1055/s-0041-1730878. Epub 2021 Jun 16.

Bisalbuminemia: A Pathologist's Insight of an Uncommon Phenomenon

Gargi Kapatia  1 , Monika Wadhwa  2 , Pankaj Malhotra  2 , Gaurav Prakash  1 , Ritu Aggarwal  1
Affiliations

Bisalbuminemia: A Pathologist's Insight of an Uncommon Phenomenon

Gargi Kapatia et al. J Lab Physicians. 2021 Sep.

Abstract

Background The incidence of a bifid electrophoretic pattern in the albumin region on serum protein electrophoresis is an infrequent phenomenon. The availability of literature from India is scarce and is limited to case reports. Objective The aim of the study is to analyze the frequency of bisalbuminemia in an Indian referral facility. The study delved into their clinical associations. Material and Methods The retrospective case records of the patient from the departmental database were scrutinized. The study subjects were for an 8-year study period. Results There were about 39,900 serum electrophoresis performed in an 8-year study period. A total of 40 cases of bisalbuminemia were detected. The incidence in our cohort was 0.01%. Conclusion Bisalbuminemia, an overtly benign condition, is infrequent in Indian population although not rare. It is associated with several clinical disorders; however, the association seems to be plausibly coincidental.

Keywords: albumin; gel electrophoresis; serum protein electrophoresis.

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Conflict of interest statement

Conflict of Interest None declared.

Figures

Fig. 1
Fig. 1
Densitometer tracing showing two peaks in the albumin region and M band on serum electrophoresis along with gel picture of bisalbuminemia with M band.
Fig. 2
Fig. 2
Serum and urine electrophoresis gel showing bisalbuminemia and bisalbuminuria, respectively.
See this image and copyright information in PMC

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