Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Review
. 2021 Sep 23:2021:3136508.
doi: 10.1155/2021/3136508. eCollection 2021.

Clinical Importance of Wnt5a in the Pathogenesis of Colorectal Cancer

Mehran Pashirzad  1 , Thozhukat Sathyapalan  2 , Amirhossein Sahebkar  3   4   5
Affiliations
Review

Clinical Importance of Wnt5a in the Pathogenesis of Colorectal Cancer

Mehran Pashirzad et al. J Oncol. .

Abstract

Wnt5a is one of the potent signaling molecules that initiates responses involved in cancer through activation of both canonical and noncanonical signaling cascades. Wnt5a both directly and indirectly triggers cancer-associated signaling pathways based on the cancer type. In colorectal cancer (CRC), altering Wnt5a expression can influence several cellular processes of tumor cells, including proliferation, differentiation, migration, invasion, and metastasis. This review summarizes the molecular mechanisms and clinical importance of Wnt5a in the pathogenesis of CRC for better understanding the pathogenesis and its potential role as a prognostic marker and as an appropriate therapeutic target in the treatment of this disease in the future.

PubMed Disclaimer

Conflict of interest statement

The authors declare that they have no conflicts of interest.

Figures

Figure 1
Figure 1
Effects of pharmacological and biological regulators on the expression levels of Wnt5a through changes of histone-modification and methylation in the CRC.
See this image and copyright information in PMC

Similar articles

See all similar articles

Cited by

References

    1. Logan C. Y., Nusse R. The Wnt signaling pathway in development and disease. Annual Review of Cell and Developmental Biology . 2004;20(1):781–810. doi: 10.1146/annurev.cellbio.20.010403.113126. - DOI - PubMed
    1. Wodarz A., Nusse R. Mechanisms of Wnt signaling in development. Annual Review of Cell and Developmental Biology . 1998;14(1):59–88. doi: 10.1146/annurev.cellbio.14.1.59. - DOI - PubMed
    1. Ghosh N., Hossain U., Mandal A., Sil P. C. The Wnt signaling pathway: a potential therapeutic target against cancer. Annals of the New York Academy of Sciences . 2019;1443(1):54–74. doi: 10.1111/nyas.14027. - DOI - PubMed
    1. Teo J.-L., Kahn M. The Wnt signaling pathway in cellular proliferation and differentiation: a tale of two coactivators. Advanced Drug Delivery Reviews . 2010;62(12):1149–1155. doi: 10.1016/j.addr.2010.09.012. - DOI - PubMed
    1. Eubelen M., Bostaille N., Cabochette P., et al. A molecular mechanism for Wnt ligand-specific signaling. Science . 2018;361(6403) doi: 10.3389/conf.fnins.2018.95.00097. - DOI - PubMed

LinkOut - more resources