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. 2021 Sep 17:8:705862.
doi: 10.3389/fcvm.2021.705862. eCollection 2021.

Association of Derived Neutrophil-To-Lymphocyte Ratio With Prognosis of Coronary Heart Disease After PCI

Gang-Qiong Liu  1 , Wen-Jing Zhang  1 , Jia-Hong Shangguan  1   2 , Xiao-Dan Zhu  1   2 , Wei Wang  2 , Qian-Qian Guo  1 , Jian-Chao Zhang  1 , Kai Wang  1 , Zhi-Yu Liu  1 , Feng-Hua Song  1 , Lei Fan  1 , Ying-Ying Zheng  1 , Jin-Ying Zhang  1
Affiliations

Association of Derived Neutrophil-To-Lymphocyte Ratio With Prognosis of Coronary Heart Disease After PCI

Gang-Qiong Liu et al. Front Cardiovasc Med. .

Abstract

Aims: The present study aimed to investigate the prognostic role of derived neutrophil-to-lymphocyte ratio (dNLR) in patients with coronary heart disease (CHD) after PCI. Methods: A total of 3,561 post-PCI patients with CHD were retrospectively enrolled in the CORFCHD-ZZ study from January 2013 to December 2017. The patients (3,462) were divided into three groups according to dNLR tertiles: the first tertile (dNLR < 1.36; n = 1,139), second tertile (1.36 ≥ dNLR < 1.96; n = 1,166), and third tertile(dNLR ≥ 1.96; n = 1,157). The mean follow-up time was 37.59 ± 22.24 months. The primary endpoint was defined as mortality (including all-cause death and cardiac death), and the secondary endpoint was major adverse cardiovascular events (MACEs) and major adverse cardiovascular and cerebrovascular events (MACCEs). Results: There were 2,644 patients with acute coronary syndrome (ACS) and 838 patients with chronic coronary syndrome (CCS) in the present study. In the total population, the all-cause mortality (ACM) and cardiac mortality (CM) incidence was significantly higher in the third tertile than in the first tertile [hazard risk (HR) = 1.8 (95% CI: 1.2-2.8), p = 0.006 and HR = 2.1 (95% CI: 1.23-3.8), p = 0.009, respectively]. Multivariate Cox regression analyses suggested that compared with the patients in the first tertile than those in the third tertile, the risk of ACM was increased 1.763 times (HR = 1.763, 95% CI: 1.133-2.743, p = 0.012), and the risk of CM was increased 1.763 times (HR = 1.961, 95% CI: 1.083-3.550, p = 0.026) in the higher dNLR group during the long-term follow-up. In both ACS patients and CCS patients, there were significant differences among the three groups in the incidence of ACM in univariate analysis. We also found that the incidence of CM was significantly different among the three groups in CCS patients in both univariate analysis (HR = 3.541, 95% CI: 1.154-10.863, p = 0.027) and multivariate analysis (HR = 3.136, 95% CI: 1.015-9.690, p = 0.047). Conclusion: The present study suggested that dNLR is an independent and novel predictor of mortality in CHD patients who underwent PCI.

Keywords: coronary heart disease; derived neutrophil-to-lymphocyte ratio; mortality; neutrophil-to-lymphocyte ratio; percutaneous coronary intervention.

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Conflict of interest statement

The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.

Figures

Figure 1
Figure 1
The follow chart of participant inclusion.
Figure 2
Figure 2
Cumulative Kaplan–Meier estimates of the time to the first adjudicated occurrence of all-cause death. (A) Total patients. (B) Acute coronary syndrome (ACS) patients. (C) Chronic coronary syndrome (CCS) patients.
Figure 3
Figure 3
Cumulative Kaplan–Meier estimates of the time to the first adjudicated occurrence of cardiac death. (A) Total Patients. (B) ACS patients. (C) CCS patients.
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