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Review
. 2021 Sep 14;6(38):24297-24303.
doi: 10.1021/acsomega.1c02563. eCollection 2021 Sep 28.

Microfluidics-Integrated Sensors toward Rapid Detection of Single Nucleotide Variations

Marziyeh Hajialyani  1 , Leila Hosseinzadeh  2 , Jie Jayne Wu  1
Affiliations
Review

Microfluidics-Integrated Sensors toward Rapid Detection of Single Nucleotide Variations

Marziyeh Hajialyani et al. ACS Omega. .

Abstract

Rapid detection of single nucleotide variations (SNVs) is of critical importance to early diagnosis of several diseases and the prediction of diverse responses to a specific treatment. Based on the information published in the literature, discrimination of SNVs is a developing area of study with great research enthusiasm and is also an area that can benefit from microfluidics-integrated designs. This review provides a brief overview of different microfluidics-based strategies for rapid detection of SNVs and mismatched bases. Sensors based on various microfluidic formats, such as paper-based microfluidic biosensors, droplet-based microfluidic systems, and magnetic bead-based microfluidic biosensors, have been discussed with respect to their specific pros and cons for SNV detection. These systems have shown promise for distributed on-site diagnostics in personalized medicine.

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Conflict of interest statement

The authors declare no competing financial interest.

Figures

Figure 1
Figure 1
Components of a lateral flow biosensor for rapid detection of SNVs. Reproduced with permission from ref (5). Copyright 2018 Elsevier.
Figure 2
Figure 2
Photograph and schematic of a droplet-based microfluidic biosensor used by Cui et al. for SNP detection. Reproduced with permission from ref (20). Copyright 2017 Elsevier.
See this image and copyright information in PMC

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