Viral Immunity and Vaccines in Hematologic Malignancies: Implications for COVID-19

doi:10.1158/2643-3230.bcd-20-0177

. 2021 Jan;2(1):9-12.

doi: 10.1158/2643-3230.bcd-20-0177. Epub 2020 Nov 2.

Viral Immunity and Vaccines in Hematologic Malignancies: Implications for COVID-19

Madhav V Dhodapkar^{1

2}, Kavita M Dhodapkar^{2

3}, Rafi Ahmed^{2

4}

Affiliations

¹ Department of Hematology/Medical Oncology, Emory University, Atlanta, Georgia.
² Winship Cancer Institute, Emory University, Atlanta, Georgia.
³ Aflac Cancer and Blood Disorders Center, Children's Healthcare of Atlanta, Emory University, Atlanta, Georgia.
⁴ Emory Vaccine Center, Emory University, Atlanta, Georgia.

PMID: 34604788
PMCID: PMC8486288
DOI: 10.1158/2643-3230.bcd-20-0177

Viral Immunity and Vaccines in Hematologic Malignancies: Implications for COVID-19

Madhav V Dhodapkar et al. Blood Cancer Discov. 2021 Jan.

. 2021 Jan;2(1):9-12.

doi: 10.1158/2643-3230.bcd-20-0177. Epub 2020 Nov 2.

Authors

Madhav V Dhodapkar^{1

2}, Kavita M Dhodapkar^{2

3}, Rafi Ahmed^{2

4}

Affiliations

¹ Department of Hematology/Medical Oncology, Emory University, Atlanta, Georgia.
² Winship Cancer Institute, Emory University, Atlanta, Georgia.
³ Aflac Cancer and Blood Disorders Center, Children's Healthcare of Atlanta, Emory University, Atlanta, Georgia.
⁴ Emory Vaccine Center, Emory University, Atlanta, Georgia.

PMID: 34604788
PMCID: PMC8486288
DOI: 10.1158/2643-3230.bcd-20-0177

Abstract

Patients with hematologic malignancies have increased susceptibility to viral infections and suboptimal immunologic responses to current vaccines due to both disease-associated and therapy-related immune dysfunction. These considerations may impact the efficacy of emerging COVID-19 vaccines in this patient population as well and warrant the need to systematically study natural and vaccine-induced virus-specific immunity in these patients.

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References

1. Wade JC. Viral infections in patients with hematological malignancies. Hematology Am Soc Hematol Educ Program 2006:368–74. - PubMed
1. Atkins S, He F. Chemotherapy and beyond: infections in the era of old and new treatments for hematologic malignancies. Infect Dis Clin North Am 2019;33:289–309. - PubMed
1. Dhodapkar MV. MGUS to myeloma: a mysterious gammopathy of underexplored significance. Blood 2016;128:2599–606. - PMC - PubMed
1. Bailur JK, McCachren SS, Doxie DB, Shrestha M, Pendleton KE, Nooka AK, et al. Early alterations in stem-like/resident T cells, innate and myeloid cells in the bone marrow in preneoplastic gammopathy. JCI Insight 2019;5:e127807. - PMC - PubMed
1. Pulendran B, Ahmed R. Immunological mechanisms of vaccination. Nat Immunol 2011;12:509–17. - PMC - PubMed

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[1] Wade JC. Viral infections in patients with hematological malignancies. Hematology Am Soc Hematol Educ Program 2006:368–74. - PubMed

[2] Wade JC. Viral infections in patients with hematological malignancies. Hematology Am Soc Hematol Educ Program 2006:368–74. - PubMed

[3] Atkins S, He F. Chemotherapy and beyond: infections in the era of old and new treatments for hematologic malignancies. Infect Dis Clin North Am 2019;33:289–309. - PubMed

[4] Atkins S, He F. Chemotherapy and beyond: infections in the era of old and new treatments for hematologic malignancies. Infect Dis Clin North Am 2019;33:289–309. - PubMed

[5] Dhodapkar MV. MGUS to myeloma: a mysterious gammopathy of underexplored significance. Blood 2016;128:2599–606. - PMC - PubMed

[6] Dhodapkar MV. MGUS to myeloma: a mysterious gammopathy of underexplored significance. Blood 2016;128:2599–606. - PMC - PubMed

[7] Bailur JK, McCachren SS, Doxie DB, Shrestha M, Pendleton KE, Nooka AK, et al. Early alterations in stem-like/resident T cells, innate and myeloid cells in the bone marrow in preneoplastic gammopathy. JCI Insight 2019;5:e127807. - PMC - PubMed

[8] Bailur JK, McCachren SS, Doxie DB, Shrestha M, Pendleton KE, Nooka AK, et al. Early alterations in stem-like/resident T cells, innate and myeloid cells in the bone marrow in preneoplastic gammopathy. JCI Insight 2019;5:e127807. - PMC - PubMed

[9] Pulendran B, Ahmed R. Immunological mechanisms of vaccination. Nat Immunol 2011;12:509–17. - PMC - PubMed

[10] Pulendran B, Ahmed R. Immunological mechanisms of vaccination. Nat Immunol 2011;12:509–17. - PMC - PubMed

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Viral Immunity and Vaccines in Hematologic Malignancies: Implications for COVID-19

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Viral Immunity and Vaccines in Hematologic Malignancies: Implications for COVID-19

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