Identification of a pyroptosis-associated long non-coding RNA signature for predicting the immune status and prognosis in skin cutaneous melanoma
- PMID: 34604952
- DOI: 10.26355/eurrev_202109_26779
Identification of a pyroptosis-associated long non-coding RNA signature for predicting the immune status and prognosis in skin cutaneous melanoma
Abstract
Objective: Pyroptosis is correlated with programmed tumor cell death and the tumor microenvironment. However, the prognostic value of pyroptosis-associated long non-coding RNAs (lncRNAs) in skin cutaneous melanoma (SKCM), a malignant tumor with a poor prognosis, has not been established.
Patients and methods: In this study, expression profiles and clinical data of patients with SKCM were downloaded from The Cancer Genome Atlas (TCGA) database to identify differentially expressed pyroptosis-related lncRNAs related to overall survival. A lncRNA risk signature was constructed by Cox regression analyses and its prognostic value was evaluated. Associations between the lncRNA signature and immune status, immune microenvironment, tumor stemness, immune checkpoints, and m6A-related genes were further evaluated.
Results: Twenty-two pyroptosis-related lncRNAs were identified and incorporated into a prognostic risk signature. The signature was significantly correlated with overall survival, tumor growth, and metastasis in SKCM. The signature demonstrated better diagnostic accuracy than conventional clinicopathological characteristics. A gene set enrichment analysis indicated that the risk signature was enriched in several immune-related pathways. Furthermore, the risk signature was significantly correlated with the immune microenvironment, immune cell infiltration, and immune subtypes, as well as tumor stem cells and some m6A-related genes. The lncRNA expression levels were also significantly related to responses to several anti-tumor drugs. Finally, a nomogram based on the risk score was established.
Conclusions: Overall, a risk signature based on 22 pyroptosis-associated lncRNAs was generated, providing a novel perspective on the determinants of prognosis and survival in SKCM and a basis for the development of individualized treatments.
Similar articles
-
A novel pyroptosis-related LncRNA signature predicts prognosis and indicates tumor immune microenvironment in skin cutaneous melanoma.Life Sci. 2022 Oct 15;307:120832. doi: 10.1016/j.lfs.2022.120832. Epub 2022 Aug 5. Life Sci. 2022. PMID: 35940218
-
Identification of m7G-associated lncRNA prognostic signature for predicting the immune status in cutaneous melanoma.Aging (Albany NY). 2022 Jun 29;14(12):5233-5249. doi: 10.18632/aging.204151. Epub 2022 Jun 29. Aging (Albany NY). 2022. PMID: 35771136 Free PMC article.
-
Development and validation of an immune gene set-based prognostic signature in cutaneous melanoma.Future Oncol. 2021 Nov;17(31):4115-4129. doi: 10.2217/fon-2021-0104. Epub 2021 Jul 22. Future Oncol. 2021. PMID: 34291650
-
Long non-coding RNAs in cutaneous melanoma: clinical perspectives.Oncotarget. 2017 Jun 27;8(26):43470-43480. doi: 10.18632/oncotarget.16478. Oncotarget. 2017. PMID: 28415644 Free PMC article. Review.
-
Comprehensive Review on the Clinical Relevance of Long Non-Coding RNAs in Cutaneous Melanoma.Int J Mol Sci. 2021 Jan 25;22(3):1166. doi: 10.3390/ijms22031166. Int J Mol Sci. 2021. PMID: 33503876 Free PMC article. Review.
Cited by
-
The Therapeutic Potential of Pyroptosis in Melanoma.Int J Mol Sci. 2023 Jan 9;24(2):1285. doi: 10.3390/ijms24021285. Int J Mol Sci. 2023. PMID: 36674798 Free PMC article. Review.
-
A novel 7‑hypoxia‑related long non‑coding RNA signature associated with prognosis and proliferation in melanoma.Mol Med Rep. 2022 Aug;26(2):255. doi: 10.3892/mmr.2022.12771. Epub 2022 Jun 15. Mol Med Rep. 2022. PMID: 35703357 Free PMC article.
-
Roles of m6A modification in oral cancer (Review).Int J Oncol. 2023 Jan;62(1):5. doi: 10.3892/ijo.2022.5453. Epub 2022 Nov 16. Int J Oncol. 2023. PMID: 36382642 Free PMC article. Review.
-
Construction of a necroptosis-related lncRNA signature to predict the prognosis and immune microenvironment of head and neck squamous cell carcinoma.J Clin Lab Anal. 2022 Jun;36(6):e24480. doi: 10.1002/jcla.24480. Epub 2022 May 6. J Clin Lab Anal. 2022. PMID: 35522142 Free PMC article.
-
Role of N6-methyladenosine RNA modification in cancer.MedComm (2020). 2024 Sep 9;5(9):e715. doi: 10.1002/mco2.715. eCollection 2024 Sep. MedComm (2020). 2024. PMID: 39252821 Free PMC article. Review.
MeSH terms
Substances
LinkOut - more resources
Full Text Sources
Medical