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. 1986 Jan;29(1):163-4.
doi: 10.1128/AAC.29.1.163.

Synthesis and antibacterial activities of optically active ofloxacin

I Hayakawa, S Atarashi, S Yokohama, M Imamura, K Sakano, M Furukawa

Synthesis and antibacterial activities of optically active ofloxacin

I Hayakawa et al. Antimicrob Agents Chemother. 1986 Jan.

Abstract

Two optically active (100% enantiomeric excess) isomers of ofloxacin [(+/-)-ofloxacin; DL-8280; (+/-)-9-fluoro-2,3-dihydro-3-methyl-10-(4-methyl-1-piperazinyl)-7-oxo-7 H-pyrido[1,2,3-de] [1,4] benzoxazine-6-carboxylic acid] were prepared by use of their optically resolved synthetic intermediates. One of the isomers, (-)-ofloxacin, was 8 to 128 times more potent in inhibiting the multiplication of gram-positive and gram-negative bacteria than the other, (+)-ofloxacin, and approximately two times more active than the racemate, (+/-)-ofloxacin.

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