Association of Serum Gamma Glutamyl Transferase and Uric Acid Levels with Impaired Fasting Glucose in Adults at a Tertiary Level Hospital of Bangladesh

Abstract

Impaired fasting glucose (IFG) is an important risk factor for overt diabetes. Gamma glutamyl transferase (GGT) is an oxidative stress maker that is synthesized in liver. Increased serum Uric Acid (UA) may reflect systemic inflammation and oxidative stress. Insulin secretion by pancreatic β cells is impaired due to oxidative stress. Serum GGT and UA levels are elevated in patients with diabetes or cardiovascular disease. The aim of this study was to explore the relationship between serum GGT and UA with IFG. This cross-sectional study was conducted on 120 subjects aged 25-55 years. The study subjects were divided into two groups with either Normal fasting glucose (NFG) or IFG according to WHO diagnostic criteria. Blood was collected to perform OGTT. Serum was separated to measure GGT, UA and lipid profile. GGT and UA levels were significantly higher (p<0.01) in IFG group than NFG group (67.23±14.40 vs. 24.19±8.41) and (7.61±1.31 vs. 4.84±1.27). Odds Ratio (OR) for IFG were 4.1 and 20.25 with GGT tertile 2 (24.0-42.0) U/L and tertile 3 (>42.0) U/L where T1 (<24.0) U/L was considered as reference category. Odds Ratio (OR) for IFG were 2.05 and 17.69 with UA tertile 2 (5.7-7.5)mg/dl and tertile 3(>7.5) mg/dl where T1 (<5.7)mg/dl was considered as reference category. Multiple regression analysis of the relation between Fasting plasma glucose (FPG) with serum GGT and UA by adjustment of other factors revealed that IFG was significantly (p<0.01) associated with serum GGT and UA.