Acute Myocarditis Following COVID-19 mRNA Vaccination in Adults Aged 18 Years or Older

doi:10.1001/jamainternmed.2021.5511

. 2021 Dec 1;181(12):1668-1670.

doi: 10.1001/jamainternmed.2021.5511.

Acute Myocarditis Following COVID-19 mRNA Vaccination in Adults Aged 18 Years or Older

Anthony Simone¹, John Herald¹, Aiyu Chen², Neil Gulati³, Albert Yuh-Jer Shen¹, Bruno Lewin⁴, Ming-Sum Lee¹

Affiliations

¹ Department of Cardiology, Kaiser Permanente Los Angeles Medical Center, Los Angeles, California.
² Department of Research and Evaluation, Kaiser Permanente Southern California, Pasadena, California.
³ Department of Cardiology, Kaiser Permanente Orange County Medical Center, Irvine, California.
⁴ Department of Family Medicine, Kaiser Permanente Los Angeles Medical Center, Los Angeles, California.

PMID: 34605853
PMCID: PMC8491129
DOI: 10.1001/jamainternmed.2021.5511

Acute Myocarditis Following COVID-19 mRNA Vaccination in Adults Aged 18 Years or Older

Anthony Simone et al. JAMA Intern Med. 2021.

. 2021 Dec 1;181(12):1668-1670.

doi: 10.1001/jamainternmed.2021.5511.

Authors

Anthony Simone¹, John Herald¹, Aiyu Chen², Neil Gulati³, Albert Yuh-Jer Shen¹, Bruno Lewin⁴, Ming-Sum Lee¹

Affiliations

¹ Department of Cardiology, Kaiser Permanente Los Angeles Medical Center, Los Angeles, California.
² Department of Research and Evaluation, Kaiser Permanente Southern California, Pasadena, California.
³ Department of Cardiology, Kaiser Permanente Orange County Medical Center, Irvine, California.
⁴ Department of Family Medicine, Kaiser Permanente Los Angeles Medical Center, Los Angeles, California.

PMID: 34605853
PMCID: PMC8491129
DOI: 10.1001/jamainternmed.2021.5511

Abstract

This cohort study examines the incidence and clinical outcomes of acute myocarditis among adults following mRNA vaccination in an integrated health care system in the US.

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Conflict of interest statement

Conflict of Interest Disclosures: None reported.

Comment in

Racial and Ethnic Differences in Age at Diabetes Diagnosis-A Call for Action.
Gopalan A, Habib AR, Grant RW. Gopalan A, et al. JAMA Intern Med. 2021 Dec 1;181(12):1560-1561. doi: 10.1001/jamainternmed.2021.4949. JAMA Intern Med. 2021. PMID: 34491279 Free PMC article. No abstract available.
COVID-19 Messenger RNA Vaccination and Myocarditis-A Rare and Mostly Mild Adverse Effect.
Guduguntla V, Katz MH. Guduguntla V, et al. JAMA Intern Med. 2021 Dec 1;181(12):1560. doi: 10.1001/jamainternmed.2021.5634. JAMA Intern Med. 2021. PMID: 34605851 No abstract available.

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COVID-19 Vaccine-Related Arthritis: A Descriptive Study of Case Reports on a Rare Complication.
Dawoud R, Haddad D, Shah V, Patel V, Abbas G, Guduru S, Dakka A, Kaushik V, Cheriyath P. Dawoud R, et al. Cureus. 2022 Jul 9;14(7):e26702. doi: 10.7759/cureus.26702. eCollection 2022 Jul. Cureus. 2022. PMID: 35959192 Free PMC article. Review.
COVID-19 vaccination and myocarditis: A review of current literature.
Dhaduk K, Khosla J, Hussain M, Mangaroliya V, Chauhan S, Ashish K, Gupta R, Pal S. Dhaduk K, et al. World J Virol. 2022 Jul 25;11(4):170-175. doi: 10.5501/wjv.v11.i4.170. World J Virol. 2022. PMID: 36159608 Free PMC article. Review.
Two Cases of Acute Myocarditis in Young Male Adults After mRNA Vaccines Against COVID-19: Similarities and Differences.
Sdogkos E, Sideri A, Kasmeridis C, Konstantinou T, Vogiatzis I. Sdogkos E, et al. Med Arch. 2022 Jun;76(3):215-220. doi: 10.5455/medarh.2022.76.215-220. Med Arch. 2022. PMID: 36200112 Free PMC article.
Myocarditis following COVID-19 vaccination in adolescents and adults: a cumulative experience of 2021.
Ilonze OJ, Guglin ME. Ilonze OJ, et al. Heart Fail Rev. 2022 Nov;27(6):2033-2043. doi: 10.1007/s10741-022-10243-9. Epub 2022 Apr 22. Heart Fail Rev. 2022. PMID: 35449353 Free PMC article. Review.

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References

1. Jeyanathan M, Afkhami S, Smaill F, Miller MS, Lichty BD, Xing Z. Immunological considerations for COVID-19 vaccine strategies. Nat Rev Immunol. 2020;20(10):615-632. doi:10.1038/s41577-020-00434-6 - DOI - PMC - PubMed
1. Polack FP, Thomas SJ, Kitchin N, et al. ; C4591001 Clinical Trial Group . Safety and efficacy of the BNT162b2 mRNA Covid-19 vaccine. N Engl J Med. 2020;383(27):2603-2615. doi:10.1056/NEJMoa2034577 - DOI - PMC - PubMed
1. Baden LR, El Sahly HM, Essink B, et al. ; COVE Study Group . Efficacy and safety of the mRNA-1273 SARS-CoV-2 vaccine. N Engl J Med. 2021;384(5):403-416. doi:10.1056/NEJMoa2035389 - DOI - PMC - PubMed
1. Kim HW, Jenista ER, Wendell DC, et al. . Patients with acute myocarditis following mRNA COVID-19 vaccination. JAMA Cardiol. 2021. doi:10.1001/jamacardio.2021.2828 - DOI - PMC - PubMed
1. Montgomery J, Ryan M, Engler R, et al. . Myocarditis following immunization with mRNA COVID-19 vaccines in members of the US military. JAMA Cardiol. 2021. doi:10.1001/jamacardio.2021.2833 - DOI - PMC - PubMed

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[1] Jeyanathan M, Afkhami S, Smaill F, Miller MS, Lichty BD, Xing Z. Immunological considerations for COVID-19 vaccine strategies. Nat Rev Immunol. 2020;20(10):615-632. doi:10.1038/s41577-020-00434-6 - DOI - PMC - PubMed

[2] Jeyanathan M, Afkhami S, Smaill F, Miller MS, Lichty BD, Xing Z. Immunological considerations for COVID-19 vaccine strategies. Nat Rev Immunol. 2020;20(10):615-632. doi:10.1038/s41577-020-00434-6 - DOI - PMC - PubMed

[3] Polack FP, Thomas SJ, Kitchin N, et al. ; C4591001 Clinical Trial Group . Safety and efficacy of the BNT162b2 mRNA Covid-19 vaccine. N Engl J Med. 2020;383(27):2603-2615. doi:10.1056/NEJMoa2034577 - DOI - PMC - PubMed

[4] Polack FP, Thomas SJ, Kitchin N, et al. ; C4591001 Clinical Trial Group . Safety and efficacy of the BNT162b2 mRNA Covid-19 vaccine. N Engl J Med. 2020;383(27):2603-2615. doi:10.1056/NEJMoa2034577 - DOI - PMC - PubMed

[5] Baden LR, El Sahly HM, Essink B, et al. ; COVE Study Group . Efficacy and safety of the mRNA-1273 SARS-CoV-2 vaccine. N Engl J Med. 2021;384(5):403-416. doi:10.1056/NEJMoa2035389 - DOI - PMC - PubMed

[6] Baden LR, El Sahly HM, Essink B, et al. ; COVE Study Group . Efficacy and safety of the mRNA-1273 SARS-CoV-2 vaccine. N Engl J Med. 2021;384(5):403-416. doi:10.1056/NEJMoa2035389 - DOI - PMC - PubMed

[7] Kim HW, Jenista ER, Wendell DC, et al. . Patients with acute myocarditis following mRNA COVID-19 vaccination. JAMA Cardiol. 2021. doi:10.1001/jamacardio.2021.2828 - DOI - PMC - PubMed

[8] Kim HW, Jenista ER, Wendell DC, et al. . Patients with acute myocarditis following mRNA COVID-19 vaccination. JAMA Cardiol. 2021. doi:10.1001/jamacardio.2021.2828 - DOI - PMC - PubMed

[9] Montgomery J, Ryan M, Engler R, et al. . Myocarditis following immunization with mRNA COVID-19 vaccines in members of the US military. JAMA Cardiol. 2021. doi:10.1001/jamacardio.2021.2833 - DOI - PMC - PubMed

[10] Montgomery J, Ryan M, Engler R, et al. . Myocarditis following immunization with mRNA COVID-19 vaccines in members of the US military. JAMA Cardiol. 2021. doi:10.1001/jamacardio.2021.2833 - DOI - PMC - PubMed

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Acute Myocarditis Following COVID-19 mRNA Vaccination in Adults Aged 18 Years or Older

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Acute Myocarditis Following COVID-19 mRNA Vaccination in Adults Aged 18 Years or Older

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