Impaired robust interhemispheric function integration of depressive brain from REST-meta-MDD database in China

Ke Deng^{1

2}, Ji-Hui Yue^{3

4}, Jian Xu⁵, Ping-Ping Ma^{1

6}, Xiao Chen^{7

8}, Le Li^{7

8}, Tong-Jian Bai⁹, Qi-Jing Bo¹⁰, Jun Cao¹¹, Guan-Mao Chen¹², Ning-Xuan Chen^{7

8}, Wei Chen¹³, Chang Cheng¹⁴, Xi-Long Cui¹⁵, Jia Duan¹⁵, Yi-Ru Fang¹⁶, Qi-Yong Gong^{17

18}, Wen-Bin Guo¹⁴, Zheng-Hua Hou¹⁹, Lan Hu¹¹, Li Kuang¹¹, Feng Li¹⁰, Tao Li²⁰, Yan-Song Liu²¹, Zhe-Ning Liu¹⁴, Yi-Cheng Long¹⁴, Qing-Hua Luo¹¹, Hua-Qing Meng¹¹, Dai-Hui Peng¹⁶, Hai-Tang Qiu¹¹, Jiang Qiu²², Yu-Shu Shi²³, Tian-Mei Si^{24

25}, Yan-Qin Tang¹⁵, Fei Wang¹⁵, Kai Wang⁹, Li Wang^{24

25}, Xiang Wang¹⁴, Ying Wang¹², Xiao-Ping Wu²⁶, Xin-Ran Wu²², Chun-Ming Xie²⁷, Guang-Rong Xie¹⁴, Hai-Yan Xie²⁸, Peng Xie^{29

30

31}, Hong Yang²³, Jian Yang³², Jia-Shu Yao¹³, Shu-Qiao Yao¹⁴, Ying-Ying Yin¹⁹, Yong-Gui Yuan¹⁹, Ai-Xia Zhang³², Hong Zhang²⁶, Ke-Rang Zhang³³, Lei Zhang^{7

8}, Zhi-Jun Zhang²⁷, Ru-Bai Zhou¹⁶, Yi-Ting Zhou²⁰, Jun-Juan Zhu¹⁶, Chao-Jie Zou¹, Cong Zhou¹, Xi-Nian Zuo^{7

8}, Chao-Gan Yan^{7

8}, Xiu-Feng Xu¹, Yu-Qi Cheng¹

Affiliations

¹ Department of Psychiatry, First Affiliated Hospital of Kunming Medical University, Kunming, Yunnan, China.
² Department of Psychiatry, The First Hospital of Jiaxing or The First Affiliated Hospital of Jiaxing University, Jiaxing, Zhejiang, China.
³ Department of Psychiatry, The Fifth Affiliated Hospital of Sun Yat-sen University, Zhuhai, Guangdong, China.
⁴ Research Center of Molecular Imaging, Fifth Affiliated Hospital of Sun Yat-sen University, Zhuhai, Guangdong, China.
⁵ Department of Rheumatology, First Affiliated Hospital of Kunming Medical University, Kunming, Yunnan, China.
⁶ Fifth People's Hospital of Zigong City, Zigong, Sichuan, China.
⁷ Department of Psychology, University of Chinese Academy of Sciences, Beijing, China.
⁸ Key Laboratory of Behavioral Science, Institute of Psychology, Chinese Academy of Sciences, Beijing, China.
⁹ Anhui Medical University, Hefei, Anhui, China.
¹⁰ Beijing Anding Hospital, Capital Medical University, Beijing, China.
¹¹ Department of Psychiatry, The First Affiliated Hospital of Chongqing Medical University, Chongqing, China.
¹² The First Affiliated Hospital of Jinan University, Guangzhou, Guangdong, China.
¹³ Department of Psychiatry, Sir Run Shaw Hospital, Zhejiang University School of Medicine, Hangzhou, Zhejiang, China.
¹⁴ Department of Psychiatry, The Second Xiangya Hospital of Central South University, Changsha, Hunan, China.
¹⁵ Department of Psychiatry, First Affiliated Hospital, China Medical University, Shenyang, Liaoning, China.
¹⁶ Department of Psychiatry, Shanghai Jiao Tong University School of Medicine, Shanghai, China.
¹⁷ Department of Radiology, Huaxi MR Research Center, West China Hospital of Sichuan University, Chengdu, Sichuan, China.
¹⁸ Psychoradiology Research Unit of Chinese Academy of Medical Sciences, West China Hospital of Sichuan University, Chengdu, Sichuan, China.
¹⁹ Department of Psychosomatics and Psychiatry, Zhongda Hospital, School of Medicine, Southeast University, Nanjing, Jiangsu, China.
²⁰ Mental Health Center, West China Hospital, Sichuan University Chengdu, Sichuan, China.
²¹ Department of Clinical Psychology, Suzhou Psychiatric Hospital, The Affiliated Guangji Hospital of Soochow University, Suzhou, Jiangsu, China.
²² Faculty of Psychology, Southwest University, Chongqing, China.
²³ Department of Radiology, The First Affiliated Hospital, College of Medicine, Zhejiang University, Hangzhou, Zhejiang, China.
²⁴ National Clinical Research Center for Mental Disorders, Peking University Sixth Hospital, Beijing, China.
²⁵ Key Laboratory of Mental Health, Ministry of Health, Peking University, Beijing, China.
²⁶ Xi'an Central Hospital, Xi'an, Shaanxi, China.
²⁷ Department of Neurology, Affiliated ZhongDa Hospital of Southeast University, Nanjing, Jiangsu, China.
²⁸ Department of Psychiatry, The Fourth Affiliated Hospital, College of Medicine, Zhejiang University, Hangzhou, Zhejiang, China.
²⁹ Institute of Neuroscience, Chongqing Medical University, Chongqing, China.
³⁰ Chongqing Key Laboratory of Neurobiology, Chongqing, China.
³¹ Department of Neurology, The First Affiliated Hospital of Chongqing Medical University, Chongqing, China.
³² The First Affiliated Hospital of Xi'an Jiaotong University, Shaanxi, China.
³³ First Hospital of Shanxi Medical University, Taiyuan, Shanxi, China.

PMID: 34606159
DOI: 10.1111/bdi.13139

Impaired robust interhemispheric function integration of depressive brain from REST-meta-MDD database in China

Ke Deng et al. Bipolar Disord. 2022 Jun.

. 2022 Jun;24(4):400-411.

doi: 10.1111/bdi.13139. Epub 2022 Mar 20.

Authors

Affiliations

¹ Department of Psychiatry, First Affiliated Hospital of Kunming Medical University, Kunming, Yunnan, China.
² Department of Psychiatry, The First Hospital of Jiaxing or The First Affiliated Hospital of Jiaxing University, Jiaxing, Zhejiang, China.
³ Department of Psychiatry, The Fifth Affiliated Hospital of Sun Yat-sen University, Zhuhai, Guangdong, China.
⁴ Research Center of Molecular Imaging, Fifth Affiliated Hospital of Sun Yat-sen University, Zhuhai, Guangdong, China.
⁵ Department of Rheumatology, First Affiliated Hospital of Kunming Medical University, Kunming, Yunnan, China.
⁶ Fifth People's Hospital of Zigong City, Zigong, Sichuan, China.
⁷ Department of Psychology, University of Chinese Academy of Sciences, Beijing, China.
⁸ Key Laboratory of Behavioral Science, Institute of Psychology, Chinese Academy of Sciences, Beijing, China.
⁹ Anhui Medical University, Hefei, Anhui, China.
¹⁰ Beijing Anding Hospital, Capital Medical University, Beijing, China.
¹¹ Department of Psychiatry, The First Affiliated Hospital of Chongqing Medical University, Chongqing, China.
¹² The First Affiliated Hospital of Jinan University, Guangzhou, Guangdong, China.
¹³ Department of Psychiatry, Sir Run Shaw Hospital, Zhejiang University School of Medicine, Hangzhou, Zhejiang, China.
¹⁴ Department of Psychiatry, The Second Xiangya Hospital of Central South University, Changsha, Hunan, China.
¹⁵ Department of Psychiatry, First Affiliated Hospital, China Medical University, Shenyang, Liaoning, China.
¹⁶ Department of Psychiatry, Shanghai Jiao Tong University School of Medicine, Shanghai, China.
¹⁷ Department of Radiology, Huaxi MR Research Center, West China Hospital of Sichuan University, Chengdu, Sichuan, China.
¹⁸ Psychoradiology Research Unit of Chinese Academy of Medical Sciences, West China Hospital of Sichuan University, Chengdu, Sichuan, China.
¹⁹ Department of Psychosomatics and Psychiatry, Zhongda Hospital, School of Medicine, Southeast University, Nanjing, Jiangsu, China.
²⁰ Mental Health Center, West China Hospital, Sichuan University Chengdu, Sichuan, China.
²¹ Department of Clinical Psychology, Suzhou Psychiatric Hospital, The Affiliated Guangji Hospital of Soochow University, Suzhou, Jiangsu, China.
²² Faculty of Psychology, Southwest University, Chongqing, China.
²³ Department of Radiology, The First Affiliated Hospital, College of Medicine, Zhejiang University, Hangzhou, Zhejiang, China.
²⁴ National Clinical Research Center for Mental Disorders, Peking University Sixth Hospital, Beijing, China.
²⁵ Key Laboratory of Mental Health, Ministry of Health, Peking University, Beijing, China.
²⁶ Xi'an Central Hospital, Xi'an, Shaanxi, China.
²⁷ Department of Neurology, Affiliated ZhongDa Hospital of Southeast University, Nanjing, Jiangsu, China.
²⁸ Department of Psychiatry, The Fourth Affiliated Hospital, College of Medicine, Zhejiang University, Hangzhou, Zhejiang, China.
²⁹ Institute of Neuroscience, Chongqing Medical University, Chongqing, China.
³⁰ Chongqing Key Laboratory of Neurobiology, Chongqing, China.
³¹ Department of Neurology, The First Affiliated Hospital of Chongqing Medical University, Chongqing, China.
³² The First Affiliated Hospital of Xi'an Jiaotong University, Shaanxi, China.
³³ First Hospital of Shanxi Medical University, Taiyuan, Shanxi, China.

PMID: 34606159
DOI: 10.1111/bdi.13139

Abstract

Background: Recently, functional homotopy (FH) architecture, defined as robust functional connectivity (FC) between homotopic regions, has been frequently reported to be altered in MDD patients (MDDs) but with divergent locations.

Methods: In this study, we obtained resting-state functional magnetic resonance imaging (R-fMRI) data from 1004 MDDs (mean age, 33.88 years; age range, 18-60 years) and 898 matched healthy controls (HCs) from an aggregated dataset from 20 centers in China. We focused on interhemispheric function integration in MDDs and its correlation with clinical characteristics using voxel-mirrored homotopic connectivity (VMHC) devised to inquire about FH patterns.

Results: As compared with HCs, MDDs showed decreased VMHC in visual, motor, somatosensory, limbic, angular gyrus, and cerebellum, particularly in posterior cingulate gyrus/precuneus (PCC/PCu) (false discovery rate [FDR] q < 0.002, z = -7.07). Further analysis observed that the reduction in SMG and insula was more prominent with age, of which SMG reflected such age-related change in males instead of females. Besides, the reduction in MTG was found to be a male-special abnormal pattern in MDDs. VMHC alterations were markedly related to episode type and illness severity. The higher Hamilton Depression Rating Scale score, the more apparent VMHC reduction in the primary visual cortex. First-episode MDDs revealed stronger VMHC reduction in PCu relative to recurrent MDDs.

Conclusions: We confirmed a significant VMHC reduction in MDDs in broad areas, especially in PCC/PCu. This reduction was affected by gender, age, episode type, and illness severity. These findings suggest that the depressive brain tends to disconnect information exchange across hemispheres.

Keywords: functional connectivity (FC); functional homotopy (FH); interhemispheric function integration; major depressive disorder (MDD); resting-state functional magnetic resonance imaging (R-fMRI); voxel-mirrored homotopic connectivity (VMHC).

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References

REFERENCES

1. Ferrari AJ, Charlson FJ, Norman RE, et al. Burden of depressive disorders by country, sex, age, and year: findings from the global burden of disease study 2010. PLoS Medicine. 2013;10(11):e1001547.
1. Schmaal L, Veltman DJ, van Erp TG, et al. Subcortical brain alterations in major depressive disorder: findings from the ENIGMA Major Depressive Disorder working group. Mol Psychiatry. 2016;21(6):806-812.
1. Schmaal L, Hibar DP, Sämann PG, et al. Cortical abnormalities in adults and adolescents with major depression based on brain scans from 20 cohorts worldwide in the ENIGMA Major Depressive Disorder Working Group. Mol Psychiatry. 2017;22(6):900-909.
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Impaired robust interhemispheric function integration of depressive brain from REST-meta-MDD database in China

Affiliations

Impaired robust interhemispheric function integration of depressive brain from REST-meta-MDD database in China

Authors

Affiliations

Abstract

References

REFERENCES

Publication types

MeSH terms

LinkOut - more resources

Full Text Sources

Medical

Research Materials

Miscellaneous