Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Review

Ampicillin Pharmacokinetics and Safety in Infants [Internet]

Daniel K Benjamin Jr.  1 , Andrew Lewandowski  2 , Ravinder Anand  2
Bethesda (MD): National Institute of Child Health and Human Development (US); 2014 Nov 24.
Best Pharmaceuticals for Children Act (BPCA) Clinical Reports.
Affiliations
Free Books & Documents
Review

Ampicillin Pharmacokinetics and Safety in Infants [Internet]

Daniel K Benjamin Jr. et al.
Free Books & Documents

Excerpt

Aim: NICHD-2012-AMP01 study was designed to characterize the pharmacokinetics (PK) and safety of ampicillin administered to infants per standard of care to address gap in pediatric labeling. Methods: The PK analysis include ampicillin data from NICHD-2011-POP01 study. The safety analysis includes ampicillin data from 1) NICHD-2011-POP01 study 2) Pediatric Pharmacology Research Unit (PPRU) study and 3) Pediatrix Medical Group Database. Results: No AEs or SAEs related to study procedures were reported. No serious, unexpected, suspected, adverse reactions to Ampicillin were reported. From the Pediatrix database Adverse events during ampicillin exposure were uncommon. Shorter dosing intervals were associated with more frequent hematologic AEs for infants of all age groups.

[Table: see text]

PubMed Disclaimer

LinkOut - more resources