Imidazo[1,2-b]pyridazine as privileged scaffold in medicinal chemistry: An extensive review

Abstract

Imidazo[1,2-b]pyridazine scaffold represents an important class of heterocyclic nucleus which provides various bioactives molecules. Among them, the successful kinase inhibitor ponatinib led to a resurgence of interest in exploring new imidazo[1,2-b]pyridazine-containing derivatives for their putative therapeutic applications in medicine. This present review intends to provide a state-of-the-art of this framework in medicinal chemistry from 1966 to nowadays, unveiling different aspects of its structure-activity relationships (SAR). This extensive literature surveil may guide medicinal chemists for the quest of novel imidazo[1,2-b]pyridazine compounds with enhanced pharmacokinetics profile and efficiency.

Keywords: Anti-inflammatory; Antibacterial; Anticancer; Antiparasitic; Antiviral; Biological activities; Imidazo[1,2-b]pyridazine; Metabolic disorders; Radiotracers; Sleeping disorders; Structure-activity relationship; Thymic enhancers.