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Meta-Analysis
. 2021 Dec;12(1):8505-8514.
doi: 10.1080/21655979.2021.1985857.

Prognostic value of CD169-positive macrophages in various tumors: a meta-analysis

Weihao Kong  1 , Meng Wei  2 , Rongqiang Liu  3 , Jianlin Zhang  1 , Xingyu Wang  1
Affiliations
Meta-Analysis

Prognostic value of CD169-positive macrophages in various tumors: a meta-analysis

Weihao Kong et al. Bioengineered. 2021 Dec.

Abstract

The study aimed to evaluate the prognostic value of CD169 expression in tumor-infiltrating macrophages from regional lymph nodes (RLN) in various tumors. In order to identify eligible articles, PubMed, EMBASE, Web of Science, and Cochrane Library were used to conduct a systematic search. Pooled hazard ratios (HRs) or odds ratios (ORs) with corresponding 95% confidence intervals (CIs) were adopted to assess the relationship between CD169 expression and overall survival (OS) and clinicopathological characteristics. Ten studies, including eleven cohorts with 1699 patients, were enrolled. We found that high CD169+ expression in tumor-infiltrating macrophages from RLN was associated with a favorable OS (HR = 0.56, 95%CI: 0.39-0.79, P = 0.001). Subgroup analysis showed that high CD169+ expression had more predictive power in digestive system tumors (HR = 0.52, 95%CI: 0.42-0.67, <0.001). In addition, high CD169 expression was significantly linked with lymph node metastasis (OR = 0.66, 95%CI: 0.47-0.94, P = 0.020) and TNM stage (OR = 0.62, 95%CI: 0.48-0.80, P < 0.001). High CD169 expression in tumor-infiltrating macrophages from RLN was correlated with favorable survival outcome in patients with malignancies. CD169 may be a novel and effective prognostic marker, especially for digestive system tumors.

Keywords: CD169; macrophages; meta-analysis; prognosis.

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Conflict of interest statement

The authors declare that they have no conflicts of interest.

Figures

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Graphical abstract
Figure 1.
Figure 1.
Flow diagram of the study selection process
Figure 2.
Figure 2.
Forest plot of the overall survival analysis
Figure 3.
Figure 3.
Sensitivity analysis of overall survival in this meta-analysis
Figure 4.
Figure 4.
Begg’s funnel plot with pseudo 95% CI of the publication bias for overall survival
See this image and copyright information in PMC

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