Critical influenza and prophylactic antifungal therapy for aspergillosis: a nuanced approach to a pertinent infectious disease

Lore Vanderbeke^{1

2}, Katrien Lagrou^{3

4}, Paul E Verweij^{5

6}, Joost Wauters^{3

7}

Affiliations

¹ Department of Microbiology, Immunology and Transplantation, KU Leuven, Leuven, Belgium. lore.vanderbeke@uzleuven.be.
² Medical Intensive Care Unit, University Hospitals Leuven, Leuven, Belgium. lore.vanderbeke@uzleuven.be.
³ Department of Microbiology, Immunology and Transplantation, KU Leuven, Leuven, Belgium.
⁴ Department of Laboratory Medicine and National Reference Center for Mycosis, University Hospitals Leuven, Leuven, Belgium.
⁵ Radboudumc-CWZ Center of Expertise for Mycology, Radboudumc Center for Infectious Diseases (RCI), Nijmegen, The Netherlands.
⁶ Department of Medical Microbiology, Radboud University Medical Center, Nijmegen, The Netherlands.
⁷ Medical Intensive Care Unit, University Hospitals Leuven, Leuven, Belgium.

Comment

Lore Vanderbeke et al. Intensive Care Med. 2021 Nov.

. 2021 Nov;47(11):1343-1344.

doi: 10.1007/s00134-021-06532-w. Epub 2021 Oct 4.

Lore Vanderbeke^{1

2}, Katrien Lagrou^{3

4}, Paul E Verweij^{5

6}, Joost Wauters^{3

7}

¹ Department of Microbiology, Immunology and Transplantation, KU Leuven, Leuven, Belgium. lore.vanderbeke@uzleuven.be.
² Medical Intensive Care Unit, University Hospitals Leuven, Leuven, Belgium. lore.vanderbeke@uzleuven.be.
³ Department of Microbiology, Immunology and Transplantation, KU Leuven, Leuven, Belgium.
⁴ Department of Laboratory Medicine and National Reference Center for Mycosis, University Hospitals Leuven, Leuven, Belgium.
⁵ Radboudumc-CWZ Center of Expertise for Mycology, Radboudumc Center for Infectious Diseases (RCI), Nijmegen, The Netherlands.
⁶ Department of Medical Microbiology, Radboud University Medical Center, Nijmegen, The Netherlands.
⁷ Medical Intensive Care Unit, University Hospitals Leuven, Leuven, Belgium.

No abstract available

Comment on

Posaconazole for prevention of invasive pulmonary aspergillosis in critically ill influenza patients (POSA-FLU): a randomised, open-label, proof-of-concept trial.
Vanderbeke L, Janssen NAF, Bergmans DCJJ, Bourgeois M, Buil JB, Debaveye Y, Depuydt P, Feys S, Hermans G, Hoiting O, van der Hoven B, Jacobs C, Lagrou K, Lemiale V, Lormans P, Maertens J, Meersseman P, Mégarbane B, Nseir S, van Oers JAH, Reynders M, Rijnders BJA, Schouten JA, Spriet I, Thevissen K, Thille AW, Van Daele R, van de Veerdonk FL, Verweij PE, Wilmer A, Brüggemann RJM, Wauters J; Dutch-Belgian Mycosis Study Group. Vanderbeke L, et al. Intensive Care Med. 2021 Jun;47(6):674-686. doi: 10.1007/s00134-021-06431-0. Epub 2021 May 29. Intensive Care Med. 2021. PMID: 34050768 Free PMC article. Clinical Trial.
Influenza and prophylactic antifungal therapy for aspergillosis: addressing some questions first.
Coste A, De Longeaux K, Aubron C. Coste A, et al. Intensive Care Med. 2021 Nov;47(11):1341-1342. doi: 10.1007/s00134-021-06488-x. Epub 2021 Aug 10. Intensive Care Med. 2021. PMID: 34374834 No abstract available.

1. Coste A, De Longeaux K, Aubron C (2021) Influenza and prophylactic antifungal therapy for aspergillosis: addressing some questions first. Intensive Care Med. https://doi.org/10.1007/s00134-021-06488-x - DOI - PubMed
1. Vanderbeke L, Janssen NAF, Bergmans DCJJ et al (2021) Posaconazole for prevention of invasive pulmonary aspergillosis in critically ill influenza patients (POSA-FLU): a randomised, open-label, proof-of-concept trial. Intensive Care Med 47:674–686. https://doi.org/10.1007/s00134-021-06431-0 - DOI - PubMed
1. Blot SI, Taccone FS, Van den Abeele AM et al (2012) A clinical algorithm to diagnose invasive pulmonary aspergillosis in critically ill patients. Am J Respir Crit Care Med 186:56–64. https://doi.org/10.1164/rccm.201111-1978OC - DOI - PubMed
1. Meersseman W, Lagrou K, Maertens J et al (2008) Galactomannan in bronchoalveolar lavage fluid: a tool for diagnosing aspergillosis in intensive care unit patients. Am J Respir Crit Care Med 177:27–34. https://doi.org/10.1164/rccm.200704-606OC - DOI - PubMed
1. Rijnders BJA, Schauwvlieghe AFAD, Wauters J (2020) Influenza-associated pulmonary aspergillosis: a local or global lethal combination? Clin Infect Dis 71:1764–1767. https://doi.org/10.1093/cid/ciaa010 - DOI - PubMed - PMC