Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Case Reports
. 2022 Feb;186(2):376-377.
doi: 10.1111/bjd.20781. Epub 2021 Nov 15.

Eruptive keratoacanthomas associated with dupilumab therapy

D Gleeson  1 , S Cliff  1 , M Das  1
Affiliations
Case Reports

Eruptive keratoacanthomas associated with dupilumab therapy

D Gleeson et al. Br J Dermatol. 2022 Feb.

Abstract

We would like to present the case of eruptive keratoacanthomas associated with dupilumab therapy, which occurred in an 85-year-old woman receiving biologic therapy for the treatment of atopic dermatitis. With the increasing prevalence of Dupilumab usage, this is an important potential complication of which clinicians should be aware.

PubMed Disclaimer

References

    1. Kong HH, Cowen EW, Azad NS et al. Keratoacanthomas associated with sorafenib therapy. J Am Acad Dermatol 2007; 56:171-2.
    1. Antonov NK, Nair KG, Halasz CL. Transient eruptive keratoacanthomas associated with nivolumab. JAAD Case Rep 2019; 5:342-5.
    1. Su F, Viros A, Milagre C et al. RAS mutations in cutaneous squamous-cell carcinomas in patients treated with BRAF inhibitors. N Engl J Med 2012; 366:207-15.
    1. He C, Carter A. The metabolic prospective and redox regulation of macrophage polarization. J Clin Cell Immunol 2015; 6:371.
    1. Goudie DR, D’Alessandro M, Merriman B et al. Multiple self-healing squamous epithelioma is caused by a disease-specific spectrum of mutations in TGFBR1. Nat Genet 2011; 43:365-9.

Substances