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Review
. 2021 Oct;9(5):e00787.
doi: 10.1002/prp2.787.

Probiotic lactobacilli in formulas and hygiene products for the health of the urogenital tract

María Elena Fátima Nader-Macías  1 , Priscilla Romina De Gregorio  1 , Jessica Alejandra Silva  1
Affiliations
Review

Probiotic lactobacilli in formulas and hygiene products for the health of the urogenital tract

María Elena Fátima Nader-Macías et al. Pharmacol Res Perspect. 2021 Oct.

Abstract

Lactobacilli are the predominant microorganisms of the healthy human vagina. A novel alternative for the prevention and treatment of female urogenital tract infections (UGTI) is the inclusion of these microorganisms as active pharmaceutical ingredients in probiotic formulas, and more recently in female hygienic products. Probiotics are defined as "live microorganisms that, when administered in adequate amounts, confer a health benefit on the host." A list of requirements must be considered during the development of probiotic product/formula for the female urogenital tract (UGT). This review aims to resume the requirements, probiotic characteristics, and clinical trial applied to determine the effect of probiotic and potentially probiotic strains on different woman's physiological and pathological conditions, and in preterm birth prevention. A revision of female hygienic products available in the world market is included, together with novel studies applying nanotechnology for Lactobacillus incorporation in hygienic products. Further studies and well-designed clinical trials are urgently required to complement the current knowledge and applications of probiotics in the female UGT. The use of probiotic formulas and products will improve and restore the ecological equilibrium of the UGT microbiome to prevent and treat UGTI in women under different conditions.

Keywords: clinical trials; female hygienic products; female urogenital tract; live biotherapeutic products; probiotics; urogenital tract infections.

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Conflict of interest statement

The authors declare there is no conflict of interest. Some of the results of the research group were included in a patent presentation (INPI, 2018, N° 20180103893).

Figures

FIGURE 1
FIGURE 1
Design and elaboration of vaginal products with beneficial probiotic bacteria (modified from reference [86]). LBP, live biotherapeutic products
FIGURE 2
FIGURE 2
Proposed mechanisms of action for probiotics in the UGT (adapted from different bibliographic references). TLR, toll‐like receptor; UGT, urogenital tract
See this image and copyright information in PMC

References

    1. Human Microbiome Project Consortium . A framework for human microbiome research. Nature. 2012;486(7402):215‐221. 10.1038/nature11209. - DOI - PMC - PubMed
    1. Verhelst R, Verstraelen H, Claeys G, et al. Comparison between Gram stain and culture for the characterization of vaginal microflora: definition of a distinct grade that resembles grade I microflora and revised categorization of grade I microflora. BMC Microbiol. 2005;5:61. 10.1186/1471-2180-5-61. - DOI - PMC - PubMed
    1. Zhou X, Hansmann MA, Davis CC, et al. The vaginal bacterial communities of Japanese women resemble those of women in other racial groups. FEMS Immunol Med Microbiol. 2010;58(2):169‐181. 10.1111/j.1574-695X.2009.00618.x. - DOI - PMC - PubMed
    1. Sroka‐Oleksiak A, Gosiewski T, Pabian W, et al. Next‐generation sequencing as a tool to detect vaginal microbiota disturbances during pregnancy. Microorganisms. 2020;8(11):1813. 10.3390/microorganisms8111813. - DOI - PMC - PubMed
    1. Fettweis JM, Serrano MG, Girerd PH, Jefferson KK, Buck GA. A new era of the vaginal microbiome: advances using next‐generation sequencing. Chem Biodivers. 2012;9(5):965‐976. 10.1002/cbdv.201100359. - DOI - PMC - PubMed

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