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. 2021 Sep 29;44(4):e20200441.
doi: 10.1590/1678-4685-GMB-2020-0441. eCollection 2021.

FABP4 and omentin-1 gene expression in epicardial adipose tissue from coronary artery disease patients

Valentina V Miroshnikova  1   2 , Ekaterina A Polyakova  1 , Irina A Pobozheva  1   2 , Aleksandra A Panteleeva  1   2 , Natalia D Razgildina  2 , Diana A Kolodina  1 , Olga D Belyaeva  1 , Olga A Berkovich  1 , Sofya N Pchelina  1   2 , Elena I Baranova  1
Affiliations

FABP4 and omentin-1 gene expression in epicardial adipose tissue from coronary artery disease patients

Valentina V Miroshnikova et al. Genet Mol Biol. .

Abstract

Omentin-1 and fatty acid-binding protein 4 (FABP4) are adipose tissue adipokines linked to obesity-associated cardiovascular complications. The aim of this study was to investigate epicardial adipose tissue (EAT) omentin-1 and FABP4 gene expression in obese and non-obese patients with coronary artery disease (CAD). Omentin-1 and FABP4 mRNA levels in EAT and paired subcutaneous adipose tissue (SAT) as well as adipokine serum concentrations were assessed in 77 individuals (61 with CAD; 16 without CAD (NCAD)). EAT FABP4 mRNA level was decreased in obese CAD patients when compared to obese NCAD individuals (p=0.001). SAT FABP4 mRNA level was decreased in CAD patients compared to NCAD individuals without respect to their obesity status (p=0.001). Omentin-1 mRNA level in EAT and SAT did not differ between the CAD and NCAD groups. These findings suggest that omentin-1 gene expression in adipose tissue is not changed during CAD; downregulated FABP4 gene expression in SAT is associated with CAD while EAT FABP4 gene expression is decreased only in obesity-related CAD.

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Conflict of interest statement

Conflict of Interest: The authors declare that they have no conflicts of interest.

Figures

Figure 1 -
Figure 1 -. FABP4 serum concentration (A) and gene expression in adipose tissue in obese and non-obese subgroups: comparative analysis of the FABP4 gene expression in subcutaneous and epicardial fat depots (B); FABP4 mRNA level in subcutaneous (C) and epicardial adipose tissue (D) in CAD and NCAD individuals.
Figure 2 -
Figure 2 -. Omentin-1 serum concentration (A) and gene expression in adipose tissue in obese and non-obese subgroups: comparative analysis of the omentin-1 gene expression in subcutaneous and epicardial fat depots (B); omentin-1 mRNA level in subcutaneous (C) and epicardial adipose tissue (D) in CAD and NCAD individuals.
See this image and copyright information in PMC

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