Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2021 Oct 5;53(5):497.
doi: 10.1007/s11250-021-02934-6.

Dietary supplementation with Piper sarmentosum extract on gut health of chickens infected with Eimeria tenella

Fareed Uddin Memon  1 , Yunqiao Yang  1 , Ahmed M Soliman  1   2 , Feifei Lv  1 , Nasir Rajput  3 , Geyin Zhang  1 , Mirza Baber Baig  4 , Yuhan Wang  1 , Hongbin Si  5
Affiliations

Dietary supplementation with Piper sarmentosum extract on gut health of chickens infected with Eimeria tenella

Fareed Uddin Memon et al. Trop Anim Health Prod. .

Abstract

To explore the potential alternative of anti-coccidials, we investigated the therapeutic efficacy of dietary Piper sarmentosum extract (PSE) on induced coccidia infection in chickens. A total of 96-day-old chickens were randomly distributed to 1 of 3 treatment groups, including (1) control negative untreated uninfected (CN), (2) control positive untreated infected (CP), and (3) Piper sarmentosum (P. sarmentosum) extract-treated infected group (PSE). Our results demonstrated that E. tenella challenged untreated group showed a reduction (P < 0.05) in post-infection (PI) body weight compared to control negative group. However, supplementation of P. sarmentosum extract had no significant effects on body weight and cecal lesions compared with control positive group. Infected chickens fed PSE diet decreased (P < 0.05) the bloody diarrhea scores and oocyst shedding (during the day 5 to 8 post-infection) than that of CP chickens. E. tenella-challenged chickens upregulated (P < 0.05) the mRNA expression of IL-8 and Bcl-2 compared to PSE chickens, while IFN-γ compared to CN chickens. On the other hand, treatment of P. sarmentosum extract tended to increase (P < 0.05) the transcription patterns of IL-4, IL-10, CLDN 1, SOD 1, and Bax with the comparison of control positive group; however, there were no significant effects on IL-8, ZO 1, and CAT expression between the PSE and CP groups. Collectively, these findings elaborated that dietary P. sarmentosum extract exhibit potential anti-coccidial effects in controlling the coccidia infection in chickens.

Keywords: Eimeria tenella, chicken; Gut health; Piper sarmentosum extract.

PubMed Disclaimer

References

    1. Abbas, A., Iqbal, Z., Abbas, R., Khan, M., Khan, J., Hussain, K., Mahmood, M. and Rizwan, H., 2017. Immunomodulatory effects of Camellia sinensis against coccidiosis in chickens, J Anim Plant Sci, 27, 415-421.
    1. Abbas, R., Iqbal, Z., Blake, D., Khan, M., and Saleemi, M., 2011. Anticoccidial drug resistance in fowl coccidia: the state of play revisited, World’s Poultry Science Journal, 67, 337-50 - DOI
    1. Akhtar, M., Hai, A., Awais, M.M., Iqbal, Z., Muhammad, F., ul Haq, A. and Anwar, M.I., 2012. Immunostimulatory and protective effects of Aloe vera against coccidiosis in industrial broiler chickens, Veterinary parasitology, 186, 170-177. - PubMed - DOI - PMC
    1. Ariffin, S.H.Z., Omar, W.H.H.W., Ariffin, Z.Z., Safian, M.F., Senafi, S. and Wahab, R.M.A., 2009. Intrinsic anticarcinogenic effects of Piper sarmentosum ethanolic extract on a human hepatoma cell line, Cancer Cell International, 9, 6. - DOI
    1. Aruoma, O.I., and Cuppett, S.L., 1997. Antioxidant methodology: in vivo and in vitro concepts, (The American Oil Chemists Society)

Publication types

LinkOut - more resources