Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2021 Sep;39(3):159-166.
doi: 10.3857/roj.2021.00339. Epub 2021 Jun 24.

Cytogenetic biological dosimetry assays: recent developments and updates

Affiliations

Cytogenetic biological dosimetry assays: recent developments and updates

Tamizh Selvan Gnanasekaran. Radiat Oncol J. 2021 Sep.

Abstract

Biological dosimetry is the measurement of radiation-induced changes in the human to measure short and long-term health risks. Biodosimetry offers an independent means of obtaining dose information and also provides diagnostic information on the potential for "partial-body" exposure information using biological indicators and otherwise based on computer modeling, dose reconstruction, and physical dosimetry. A variety of biodosimetry tools are available and some features make some more valuable than others. Among the available biodosimetry tool, cytogenetic biodosimetry methods occupy an exclusive and advantageous position. The cytogenetic analysis can complement physical dosimetry by confirming or ruling out an accidental radiological exposure or overexposures. We are discussing the recent developments and adaptability of currently available cytogenetic biological dosimetry assays.

Keywords: Biological dosimetry; Cytogenetics; Radiation.

PubMed Disclaimer

Conflict of interest statement

Conflict of Interest

No potential conflict of interest relevant to this article was reported.

References

    1. United Nations Scientific Committee on the Effects of Atomic Radiation . UNSCEAR 2008 Report: Sources and effects of ionizing radiation. Vienna, Austria: United Nations Scientific Committee on the Effects of Atomic Radiation; 2011.
    1. World Health Organization . The Great East Japan Earthquake: a story of devastating natural disaster, a tale of human compassion. Manila, Philippines: World Health Organization; 2012.
    1. Vorobiev AI. Acute radiation disease and biological dosimetry in 1993. Stem Cells. 1997;15 Suppl 2:269–74. - PubMed
    1. Ramalho AT, Nascimento AC, Natarajan AT. Dose assessments by cytogenetic analysis in the Goiania (Brazil) radiation accident. Radiat Prot Dosim. 1988;25:97–100.
    1. Rigaud O, Laquerbe A, Moustacchi E. DNA sequence analysis of HPRT- mutants induced in human lymphoblastoid cells adapted to ionizing radiation. Radiat Res. 1995;144:181–9. - PubMed

LinkOut - more resources