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. 2022 Feb;32(2):98-101.
doi: 10.1016/j.tcb.2021.09.001. Epub 2021 Oct 2.

Chromatin dynamics in human brain development and disease

Alfredo M Valencia  1 , Sergiu P Pașca  2
Affiliations

Chromatin dynamics in human brain development and disease

Alfredo M Valencia et al. Trends Cell Biol. 2022 Feb.

Abstract

Chromatin-related genes are frequently mutated in neurodevelopmental disorders; yet, the mechanisms by which these perturbations disrupt brain assembly and function are not understood. Here, we describe how recent advances in transcriptional and chromatin profiling in combination with cellular models are beginning to inform our understanding of neurodevelopment and chromatinopathies.

Keywords: assembloids; chromatin; chromatinopathies; neurodevelopment; organoids.

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Conflict of interest statement

Declaration of interests The authors have no interests to declare.

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