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Review
. 2021 Apr 5:7:100179.
doi: 10.1016/j.ajpc.2021.100179. eCollection 2021 Sep.

Oral health and atherosclerotic cardiovascular disease: A review

Eugenia Gianos  1 , Elizabeth A Jackson  2 , Astha Tejpal  1 , Karen Aspry  3 , James O'Keefe  4 , Monica Aggarwal  5 , Ankur Jain  5 , Dipti Itchhaporia  6 , Kim Williams  7 , Travis Batts  8 , Kathleen E Allen  9 , Clark Yarber  10 , Robert J Ostfeld  11 , Michael Miller  12 , Koushik Reddy  13 , Andrew M Freeman  14 , Kenneth E Fleisher  15
Affiliations
Review

Oral health and atherosclerotic cardiovascular disease: A review

Eugenia Gianos et al. Am J Prev Cardiol. .

Abstract

Periodontal disease (PD) is common in the US and globally. Evidence suggests that poor oral health is associated with atherosclerotic cardiovascular disease (ASCVD); however, this relationship has not been a major focus in clinical cardiology. This manuscript will review the growing evidence linking PD to ASCVD, including pathophysiologic mechanisms and coexistent risk factors. Public health considerations with a focus on disparities, social determinants, preventive strategies, and a call to action to reduce the burden of coincident ASCVD and PD are also reviewed.

Keywords: Cardiovascular Disease; Cardiovascular prevention; Oral health; Periodontal disease.

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Conflict of interest statement

EAJ Research funding: (NIH [R01AG045136, UL1TR001417, UOA-212,513, P30CA013148-47S6], Amgen; Consulting: ACC, McKesson; Roylaties: UpToDate; Editorial Board: American Heart Association; JOK major ownership interest: CardioTabs; DI Research Funding Amgen; RO Consulting: Better Therapeutics; AMF: Speaker Board Boehringer-Ingleheim; All other authors have nothing to disclose.

Figures

Image, graphical abstract
Graphical abstract
Fig 1
Fig. 1
(central illustration): Proposed mechanisms linking dental disease and atherosclerosis. IL: Interleukin; CRP: C-reactive protein; MMP: Matrix metalloproteinase; TLR: Toll-like receptor; NO: Nitric oxide; PG: Proteoglycan; LP: Lipoprotein.
See this image and copyright information in PMC

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