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. 2022 Jan;16(1):7-13.
doi: 10.1111/irv.12915. Epub 2021 Oct 5.

Early epidemiological investigations: World Health Organization UNITY protocols provide a standardized and timely international investigation framework during the COVID-19 pandemic

Isabel Bergeri  1 , Hannah C Lewis  1 , Lorenzo Subissi  1 , Anthony Nardone  1   2 , Marta Valenciano  1   2 , Brianna Cheng  1 , Ketevan Glonti  1 , Bridget Williams  1 , Ibukun-Oluwa Omolade Abejirinde  1 , Alice Simniceanu  1 , Alessandro Cassini  1 , Rebecca Grant  1 , Angel Rodriguez  3 , Andrea Vicari  3 , Lubna Al Ariqi  4 , Tasnim Azim  5 , Pushpa Ranjan Wijesinghe  5 , Soatiana Cathycia Rajatonirina  6 , Joseph Chukwudi Okeibunor  6 , Linh-Vi Le  7 , Mark Katz  8 , Aisling Vaughan  8 , Pernille Jorgensen  8 , Gudrun Freidl  8 , Richard Pebody  8 , Maria D Van Kerkhove  1
Affiliations

Early epidemiological investigations: World Health Organization UNITY protocols provide a standardized and timely international investigation framework during the COVID-19 pandemic

Isabel Bergeri et al. Influenza Other Respir Viruses. 2022 Jan.

Abstract

Background: The declaration of Coronavirus disease 2019 (COVID-19) as a Public Health Emergency of International Concern (PHEIC) on 30 January 2020 required rapid implementation of early investigations to inform appropriate national and global public health actions.

Methods: The suite of existing pandemic preparedness generic epidemiological early investigation protocols was rapidly adapted for COVID-19, branded the 'UNITY studies' and promoted globally for the implementation of standardized and quality studies. Ten protocols were developed investigating household (HH) transmission, the first few cases (FFX), population seroprevalence (SEROPREV), health facilities transmission (n = 2), vaccine effectiveness (n = 2), pregnancy outcomes and transmission, school transmission, and surface contamination. Implementation was supported by WHO and its partners globally, with emphasis to support building surveillance and research capacities in low- and middle-income countries (LMIC).

Results: WHO generic protocols were rapidly developed and published on the WHO website, 5/10 protocols within the first 3 months of the response. As of 30 June 2021, 172 investigations were implemented by 97 countries, of which 62 (64%) were LMIC. The majority of countries implemented population seroprevalence (71 countries) and first few cases/household transmission (37 countries) studies.

Conclusion: The widespread adoption of UNITY protocols across all WHO regions indicates that they addressed subnational and national needs to support local public health decision-making to prevent and control the pandemic.

Keywords: COVID-19; SARS-CoV-2; infectious diseases; seroepidemiology; serology; seroprevalence.

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Figures

FIGURE 1
FIGURE 1
Insignia of WHO UNITY early investigations initiative
FIGURE 2
FIGURE 2
Countries that have started implementing at least one sero‐epidemiological investigation aligned with WHO UNITY generic protocols, from Jan 2020 to 30 June 2021
See this image and copyright information in PMC

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